Component
HIF stabilization in butyrate-exposed human epithelial cells
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Butyrate still stabilized HIF in human epithelial-cell experiments when its beta-oxidation and associated oxygen consumption were inhibited.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human cell experiments with beta-oxidation inhibition.
- limitations
- Pharmacological inhibition has limitations; the complementary purified-PHD2 assay supports a separate mechanism.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- Fuel burning was not the only way it influenced HIF.
- primary_references
- Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34190032/ · DOI 10.1080/19490976.2021.1938380
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 254–260
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human cell experiments with beta-oxidation inhibition. · source_derived_draft · unverified_draft
## butyrate-hif-without-oxidation Fuel burning was not the only way it influenced HIF. Butyrate still stabilized HIF in human epithelial-cell experiments when its beta-oxidation and associated oxygen consumption were inhibited. Model: Human cell experiments with beta-oxidation inhibition. Limitations: Pharmacological inhibition has limitations; the complementary purified-PHD2 assay supports a separate mechanism. Evidence access: Primary abstract Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. · 2021 · https://pubmed.ncbi.nlm.nih.gov/34190032/ · DOI 10.1080/19490976.2021.1938380
Complete structured claim and evidenceButyrate increased epithelial oxygen consumption and stabilized HIF in intestinal epithelial-cell experiments.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human intestinal epithelial cultures, with separate mouse depletion/repletion experiments.
- limitations
- HIF stabilization has more than one possible route; this result does not exclude direct hydroxylase inhibition.
- nutrient_topic
- Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
- plain_language
- Using the fuel changed local oxygen sensing.
- primary_references
- Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25865369/ · DOI 10.1016/j.chom.2015.03.005
Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 238–244
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human intestinal epithelial cultures, with separate mouse depletion/repletion experiments. · source_derived_draft · unverified_draft
## butyrate-oxygen-hif Using the fuel changed local oxygen sensing. Butyrate increased epithelial oxygen consumption and stabilized HIF in intestinal epithelial-cell experiments. Model: Human intestinal epithelial cultures, with separate mouse depletion/repletion experiments. Limitations: HIF stabilization has more than one possible route; this result does not exclude direct hydroxylase inhibition. Evidence access: Primary abstract Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25865369/ · DOI 10.1016/j.chom.2015.03.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.