Component

Human breath allyl-methyl-sulfide exposure over 32 hours

Human breath allyl-methyl-sulfide exposure over 32 hours. Interpret through the linked study species, preparation, exposure and measured endpoint.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The tested preparation gave 36-104% relative breath AMS exposure versus homogenized raw garlic.

    Enteric garlic tablets in the 2018 breath study → Human breath allyl-methyl-sulfide exposure over 32 hours Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_model
    Thirteen participants across preparation comparisons; 32-hour breath metabolite AUC.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Indirect relative marker; not percent intact allicin entering blood or efficacy equivalence.
    plain_language
    The tested preparation gave 36-104% relative breath AMS exposure versus homogenized raw garlic.
    primary_references
    Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods. | 2018 | DOI 10.3390/nu10070812 | PMID 29937536 | https://pubmed.ncbi.nlm.nih.gov/29937536/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6073756/ | https://doi.org/10.3390/nu10070812
    source_locator
    Reviewed reference lines 29-29; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 29–29

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Thirteen participants across preparation comparisons; 32-hour breath metabolite AUC. · Recorded from source · Recorded from source

    **Human breath measurements.** Lawson and Hunsaker compared preparations using thirty-two-hour breath allyl methyl sulfide (AMS) exposure in thirteen participants. Their relative results were 80–111% for tested non-enteric tablets, 36–104% for enteric tablets, and 22–57% for enteric products with high-protein meals, relative to homogenized raw garlic. These percentages are not absolute bioavailability of intact plasma allicin. The study also found contributions from SAC-related precursors to AMS, particularly relevant to preparations with inhibited alliinase. Thus AMS is a useful preparation-comparison marker with chemical-origin limitations. Enteric coating is not automatically superior. Meal effects, disintegration, enzyme activity, and the assay all matter. [Lawson and Hunsaker 2018](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073756/)
    Complete structured claim and evidence

  2. The tested preparation gave 80-111% relative breath AMS exposure versus homogenized raw garlic.

    Non-enteric garlic tablets in the 2018 breath study → Human breath allyl-methyl-sulfide exposure over 32 hours Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_model
    Thirteen participants across preparation comparisons; 32-hour breath metabolite AUC.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Indirect relative marker; not percent intact allicin entering blood or efficacy equivalence.
    plain_language
    The tested preparation gave 80-111% relative breath AMS exposure versus homogenized raw garlic.
    primary_references
    Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods. | 2018 | DOI 10.3390/nu10070812 | PMID 29937536 | https://pubmed.ncbi.nlm.nih.gov/29937536/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6073756/ | https://doi.org/10.3390/nu10070812
    source_locator
    Reviewed reference lines 29-29; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 29–29

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Thirteen participants across preparation comparisons; 32-hour breath metabolite AUC. · Recorded from source · Recorded from source

    **Human breath measurements.** Lawson and Hunsaker compared preparations using thirty-two-hour breath allyl methyl sulfide (AMS) exposure in thirteen participants. Their relative results were 80–111% for tested non-enteric tablets, 36–104% for enteric tablets, and 22–57% for enteric products with high-protein meals, relative to homogenized raw garlic. These percentages are not absolute bioavailability of intact plasma allicin. The study also found contributions from SAC-related precursors to AMS, particularly relevant to preparations with inhibited alliinase. Thus AMS is a useful preparation-comparison marker with chemical-origin limitations. Enteric coating is not automatically superior. Meal effects, disintegration, enzyme activity, and the assay all matter. [Lawson and Hunsaker 2018](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073756/)
    Complete structured claim and evidence

  3. A high-protein meal reduced relative breath AMS exposure from the tested enteric products to 22-57%.

    Enteric garlic tablets in the 2018 breath study → Human breath allyl-methyl-sulfide exposure over 32 hours Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_condition
    Same products with low-protein meal administered · Enteric garlic tablets in the 2018 breath study Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Same products with low-protein meal co-administered · High-protein meal used in the 2018 garlic tablet comparison Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Enteric tablets with high-protein meal", "comparator": "Same products with low-protein meal", "endpoint": "A high-protein meal reduced relative breath AMS exposure from the tested enteric products to 22-57%.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "garlic-enteric-lawson-2018", "state": "administered"}, {"entity_slug": "high-protein-meal-lawson-2018", "state": "co-administered"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Human enteric-tablet/meal comparison; breath AMS AUC.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Joint formulation-meal exposure; not a general protein-induced inhibition of allicin or clinical benefit.
    plain_language
    A high-protein meal reduced relative breath AMS exposure from the tested enteric products to 22-57%.
    primary_references
    Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods. | 2018 | DOI 10.3390/nu10070812 | PMID 29937536 | https://pubmed.ncbi.nlm.nih.gov/29937536/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6073756/ | https://doi.org/10.3390/nu10070812
    source_locator
    Reviewed reference lines 29-29; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 29–29

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human enteric-tablet/meal comparison; breath AMS AUC. · Recorded from source · Recorded from source

    **Human breath measurements.** Lawson and Hunsaker compared preparations using thirty-two-hour breath allyl methyl sulfide (AMS) exposure in thirteen participants. Their relative results were 80–111% for tested non-enteric tablets, 36–104% for enteric tablets, and 22–57% for enteric products with high-protein meals, relative to homogenized raw garlic. These percentages are not absolute bioavailability of intact plasma allicin. The study also found contributions from SAC-related precursors to AMS, particularly relevant to preparations with inhibited alliinase. Thus AMS is a useful preparation-comparison marker with chemical-origin limitations. Enteric coating is not automatically superior. Meal effects, disintegration, enzyme activity, and the assay all matter. [Lawson and Hunsaker 2018](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073756/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.