Component
Human glycine decarboxylase / GLDC
Human glycine decarboxylase / GLDC
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human GLDC cDNA sequencing identified a conserved PLP-binding lysine region corresponding to the chicken enzyme.
Experimental context and source evidence
- experimental_model
- Human and chicken cDNA cloning and sequence comparison
- limitations
- Sequence evidence; human catalytic rates were not established by this cloning study.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- The human enzyme retains the conserved B6-binding machinery.
- primary_references
- [b6-gldc-1991] The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures. (1991). https://pubmed.ncbi.nlm.nih.gov/1993704/ DOI: 10.1016/s0021-9258(18)49991-7
- tissue_or_cell_type
- Cloned human GLDC cDNA and deduced protein sequence
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 671–680
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human and chicken cDNA cloning and sequence comparison · source_derived_draft · unverified_draft
### b6-met-human-gldc-plp-site Human GLDC cDNA sequencing identified a conserved PLP-binding lysine region corresponding to the chicken enzyme. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The human enzyme retains the conserved B6-binding machinery. organism: Homo sapiens tissue_or_cell_type: Cloned human GLDC cDNA and deduced protein sequence experimental_model: Human and chicken cDNA cloning and sequence comparison limitations: Sequence evidence; human catalytic rates were not established by this cloning study. [b6-gldc-1991] The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures. (1991). https://pubmed.ncbi.nlm.nih.gov/1993704/ DOI: 10.1016/s0021-9258(18)49991-7
Complete structured claim and evidence
Where it participates (unsigned role)
Human AMT transfers the aminomethyl-lipoyl intermediate's carbon to tetrahydrofolate, yielding 5,10-methylene-THF, ammonia and reduced H-protein.
Experimental context and source evidence
- cross_nutrient
- B6-dependent GLDC precedes lipoyl-carrier transfer and folate-dependent AMT chemistry.
- experimental_model
- Purified human AMT structures and mutational analyses
- limitations
- AMT is the directly examined human enzyme; this study did not test dietary B6 depletion or the entire pathway flux.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- Glycine cleavage connects its B6-dependent first step to a separate folate-dependent step.
- primary_references
- [b6-amt-2005] Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia. (2005). https://pubmed.ncbi.nlm.nih.gov/16051266/ DOI: 10.1016/j.jmb.2005.06.056
- tissue_or_cell_type
- Purified recombinant protein; no intact tissue
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 682–692
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human AMT structures and mutational analyses · source_derived_draft · unverified_draft
### b6-met-amt-onecarbon Human AMT transfers the aminomethyl-lipoyl intermediate's carbon to tetrahydrofolate, yielding 5,10-methylene-THF, ammonia and reduced H-protein. Condition category: normal nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Glycine cleavage connects its B6-dependent first step to a separate folate-dependent step. organism: Homo sapiens tissue_or_cell_type: Purified recombinant protein; no intact tissue experimental_model: Purified human AMT structures and mutational analyses limitations: AMT is the directly examined human enzyme; this study did not test dietary B6 depletion or the entire pathway flux. cross_nutrient: B6-dependent GLDC precedes lipoyl-carrier transfer and folate-dependent AMT chemistry. [b6-amt-2005] Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia. (2005). https://pubmed.ncbi.nlm.nih.gov/16051266/ DOI: 10.1016/j.jmb.2005.06.056
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.