Component

Gallic acid

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The studied E. coli AroE system supported NADP+-dependent DHS oxidation toward gallic acid.

    3-Dehydroshikimate / DHS → Gallic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
    experimental_model
    Purified enzyme oxidative branch with subsequent spontaneous aromatization proposed in the paper, distinct from NADPH-driven DHS reduction.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    The studied E. coli AroE system supported NADP+-dependent DHS oxidation toward gallic acid.
    primary_references
    Mechanism of gallic acid biosynthesis in bacteria (Escherichia coli) and walnut (Juglans regia). | 2011 | DOI 10.1007/s11103-011-9739-3 | PMID 21279669 | https://pubmed.ncbi.nlm.nih.gov/21279669/ | https://doi.org/10.1007/s11103-011-9739-3 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3057006/
    source_locator
    Reviewed reference lines 87-87; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 87–87

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Purified enzyme oxidative branch with subsequent spontaneous aromatization proposed in the paper, distinct from NADPH-driven DHS reduction. · source_derived_draft · unverified_draft

    **A plant oxidative branch is not a human metabolic pathway.** Walnut shikimate-dehydrogenase work and E. coli AroE assays support oxidation of DHS toward gallic acid with NADP+ in the studied enzyme systems; expression of walnut JrSDH in tobacco increased gallic-acid accumulation. This branch shows why substrate and redox context matter for enzyme function. It is not evidence that oral shikimic acid is converted into gallic acid by a human shikimate pathway. [Mechanism of gallic acid biosynthesis in bacteria (Escherichia coli) and walnut (Juglans regia).](https://pubmed.ncbi.nlm.nih.gov/21279669/)
    Complete structured claim and evidence

  2. Walnut shikimate dehydrogenase supports the studied oxidative route toward gallic acid.

    3-Dehydroshikimate / DHS → Gallic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
    experimental_model
    Walnut enzyme assays and transgenic tobacco context; not a human pathway.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    Walnut shikimate dehydrogenase supports the studied oxidative route toward gallic acid.
    primary_references
    Mechanism of gallic acid biosynthesis in bacteria (Escherichia coli) and walnut (Juglans regia). | 2011 | DOI 10.1007/s11103-011-9739-3 | PMID 21279669 | https://pubmed.ncbi.nlm.nih.gov/21279669/ | https://doi.org/10.1007/s11103-011-9739-3 | https://pmc.ncbi.nlm.nih.gov/articles/PMC3057006/
    source_locator
    Reviewed reference lines 87-87; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 87–87

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Walnut enzyme assays and transgenic tobacco context; not a human pathway. · source_derived_draft · unverified_draft

    **A plant oxidative branch is not a human metabolic pathway.** Walnut shikimate-dehydrogenase work and E. coli AroE assays support oxidation of DHS toward gallic acid with NADP+ in the studied enzyme systems; expression of walnut JrSDH in tobacco increased gallic-acid accumulation. This branch shows why substrate and redox context matter for enzyme function. It is not evidence that oral shikimic acid is converted into gallic acid by a human shikimate pathway. [Mechanism of gallic acid biosynthesis in bacteria (Escherichia coli) and walnut (Juglans regia).](https://pubmed.ncbi.nlm.nih.gov/21279669/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.