Component
Production of functional mouse oocytes
Oocytes capable of completing meiosis and contributing to offspring in the ovarian graft experiment.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
RAR-null fetal ovaries grafted into adult females produced oocytes that contributed to offspring carrying the deleted alleles.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Ovarian graft and breeding experiment
- exposure
- E17.5 mutant ovaries grafted into nude females; mating with wild-type males.
- limitations
- Recipient support bypassed mutant fetal lethality; not intact-knockout fertility.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- The receptor-deficient ovarian grafts could produce functional eggs.
- primary_references
- [vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. (2020). https://pubmed.ncbi.nlm.nih.gov/32917583/ DOI: 10.1126/sciadv.aaz1139
- tissue_or_cell_type
- fetal ovarian graft in adult recipient
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 317–328
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ovarian graft and breeding experiment · source_derived_draft · unverified_draft
### va-repro-rar-null-functional-oocytes RAR-null fetal ovaries grafted into adult females produced oocytes that contributed to offspring carrying the deleted alleles. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: The receptor-deficient ovarian grafts could produce functional eggs. organism: Mus musculus tissue_or_cell_type: fetal ovarian graft in adult recipient experimental_model: Ovarian graft and breeding experiment limitations: Recipient support bypassed mutant fetal lethality; not intact-knockout fertility. exposure: E17.5 mutant ovaries grafted into nude females; mating with wild-type males. cross_nutrient: false [vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. (2020). https://pubmed.ncbi.nlm.nih.gov/32917583/ DOI: 10.1126/sciadv.aaz1139
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.