{"id":"cbb827eb-92cc-57f6-8887-47c9b58f1a1f","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-rar-null-functional-oocytes","predicate":"absence_permits","statement":"RAR-null fetal ovaries grafted into adult females produced oocytes that contributed to offspring carrying the deleted alleles.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"b57c1541-f67d-58a0-8eea-508e4854ac12","mechanism_event_label":"The receptor-deficient ovarian grafts could produce functional eggs.","subject":{"id":"0453bf0c-3c7c-5275-9b9e-8d7f01613b51","slug":"rar-family","display_name":"Retinoic acid receptor family","entity_type_key":"protein_family"},"object":{"id":"6b793064-5aae-530c-803f-3f71dcf7af6c","slug":"functional-mouse-oocyte-production","display_name":"Production of functional mouse oocytes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b57c1541-f67d-58a0-8eea-508e4854ac12","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-rar-null-functional-oocytes-event","event_type":"biochemical_relationship","label":"The receptor-deficient ovarian grafts could produce functional eggs.","description":"RAR-null fetal ovaries grafted into adult females produced oocytes that contributed to offspring carrying the deleted alleles.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"231bc87f-843e-57b3-ad84-06f63f656383","slug":"rara","display_name":"Retinoic acid receptor alpha","entity_type_key":"protein"},"role":"deleted_receptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1ab58d8f-c076-5814-ac44-1492046497ae","slug":"rarb","display_name":"Retinoic acid receptor beta","entity_type_key":"protein"},"role":"deleted_receptor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e3d36f8c-f454-5b21-8539-6e8f5eab3d8e","slug":"rarg","display_name":"Retinoic acid receptor gamma","entity_type_key":"protein"},"role":"deleted_receptor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0453bf0c-3c7c-5275-9b9e-8d7f01613b51","slug":"rar-family","display_name":"Retinoic acid receptor family","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6b793064-5aae-530c-803f-3f71dcf7af6c","slug":"functional-mouse-oocyte-production","display_name":"Production of functional mouse oocytes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ovarian graft and breeding experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"E17.5 mutant ovaries grafted into nude females; mating with wild-type males.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Recipient support bypassed mutant fetal lethality; not intact-knockout fertility.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The receptor-deficient ovarian grafts could produce functional eggs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. (2020). https://pubmed.ncbi.nlm.nih.gov/32917583/ DOI: 10.1126/sciadv.aaz1139","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"fetal ovarian graft in adult recipient","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e95fd7a4-287d-508c-9c75-fef46296cfcf","evidence_kind":"source_excerpt","locator":"Lines 317-328","start_line":317,"end_line":328,"excerpt":"### va-repro-rar-null-functional-oocytes\nRAR-null fetal ovaries grafted into adult females produced oocytes that contributed to offspring carrying the deleted alleles.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The receptor-deficient ovarian grafts could produce functional eggs.\norganism: Mus musculus\ntissue_or_cell_type: fetal ovarian graft in adult recipient\nexperimental_model: Ovarian graft and breeding experiment\nlimitations: Recipient support bypassed mutant fetal lethality; not intact-knockout fertility.\nexposure: E17.5 mutant ovaries grafted into nude females; mating with wild-type males.\ncross_nutrient: false\n[vernet2020] Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors. 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