Component
Forearm endothelium-dependent vasodilation
Forearm endothelium-dependent vasodilation. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In statin-treated CVD patients, lycopene improved endothelium-dependent vasodilation by 53% versus placebo, 95% CI 9% to 93%.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/24911964.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9", "start_char": 0, "end_char": 1849, "text_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9"}
- experimental_model
- Double-blind placebo-controlled trial
- exposure
- 7 mg lycopene daily for two months
- limitations
- Surrogate physiology, not cardiovascular events; CVD and healthy populations analyzed separately.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human, 36 statin-treated CVD patients and 36 healthy volunteers
- plain_language
- A blood-vessel response improved in the patient group.
- primary_references
- [lycopene-p24911964] Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24911964/ DOI: 10.1371/journal.pone.0099070
- tissue_or_cell_type
- Forearm vascular responses
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 962–973
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### lycopene-cvd-edv In statin-treated CVD patients, lycopene improved endothelium-dependent vasodilation by 53% versus placebo, 95% CI 9% to 93%. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: A blood-vessel response improved in the patient group. organism: Human, 36 statin-treated CVD patients and 36 healthy volunteers tissue_or_cell_type: Forearm vascular responses experimental_model: Double-blind placebo-controlled trial limitations: Surrogate physiology, not cardiovascular events; CVD and healthy populations analyzed separately. exposure: 7 mg lycopene daily for two months evidence_span: {"source_cache": "artifacts/lycopene-research/24911964.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9", "start_char": 0, "end_char": 1849, "text_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9"} [lycopene-p24911964] Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24911964/ DOI: 10.1371/journal.pone.0099070
Complete structured claim and evidenceHealthy volunteers did not show an improvement in endothelium-dependent vasodilation after lycopene.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/24911964.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9", "start_char": 0, "end_char": 1849, "text_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9"}
- experimental_model
- Double-blind placebo-controlled trial
- exposure
- 7 mg lycopene daily for two months
- limitations
- Surrogate physiology, not cardiovascular events; CVD and healthy populations analyzed separately.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human, 36 statin-treated CVD patients and 36 healthy volunteers
- plain_language
- The finding was not universal across participants.
- primary_references
- [lycopene-p24911964] Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24911964/ DOI: 10.1371/journal.pone.0099070
- tissue_or_cell_type
- Forearm vascular responses
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 975–986
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### lycopene-healthy-edv-null Healthy volunteers did not show an improvement in endothelium-dependent vasodilation after lycopene. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: The finding was not universal across participants. organism: Human, 36 statin-treated CVD patients and 36 healthy volunteers tissue_or_cell_type: Forearm vascular responses experimental_model: Double-blind placebo-controlled trial limitations: Surrogate physiology, not cardiovascular events; CVD and healthy populations analyzed separately. exposure: 7 mg lycopene daily for two months evidence_span: {"source_cache": "artifacts/lycopene-research/24911964.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9", "start_char": 0, "end_char": 1849, "text_sha256": "d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9"} [lycopene-p24911964] Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24911964/ DOI: 10.1371/journal.pone.0099070
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.