{"id":"c083f193-5b84-54d7-bd8c-2a9732b058c5","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-healthy-edv-null","predicate":"did_not_improve","statement":"Healthy volunteers did not show an improvement in endothelium-dependent vasodilation after lycopene.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6c4b7f67-bced-54ea-8b98-45ddf8fcd29f","mechanism_event_label":"The finding was not universal across participants.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"f7ef9a9b-fc70-5383-a6b3-ed69fe76364a","slug":"forearm-endothelium-dependent-vasodilation","display_name":"Forearm endothelium-dependent vasodilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6c4b7f67-bced-54ea-8b98-45ddf8fcd29f","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-healthy-edv-null-event","event_type":"biochemical_relationship","label":"The finding was not universal across participants.","description":"Healthy volunteers did not show an improvement in endothelium-dependent vasodilation after lycopene.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f7ef9a9b-fc70-5383-a6b3-ed69fe76364a","slug":"forearm-endothelium-dependent-vasodilation","display_name":"Forearm endothelium-dependent vasodilation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/24911964.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9\", \"start_char\": 0, \"end_char\": 1849, \"text_sha256\": \"d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"7 mg lycopene daily for two months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Surrogate physiology, not cardiovascular events; CVD and healthy populations analyzed separately.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 36 statin-treated CVD patients and 36 healthy volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The finding was not universal across participants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p24911964] Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24911964/ DOI: 10.1371/journal.pone.0099070","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Forearm vascular responses","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"04735205-312e-53bb-9833-9e0c1c738912","evidence_kind":"source_excerpt","locator":"Lines 975-986","start_line":975,"end_line":986,"excerpt":"### lycopene-healthy-edv-null\nHealthy volunteers did not show an improvement in endothelium-dependent vasodilation after lycopene.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The finding was not universal across participants.\norganism: Human, 36 statin-treated CVD patients and 36 healthy volunteers\ntissue_or_cell_type: Forearm vascular responses\nexperimental_model: Double-blind placebo-controlled trial\nlimitations: Surrogate physiology, not cardiovascular events; CVD and healthy populations analyzed separately.\nexposure: 7 mg lycopene daily for two months\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/24911964.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9\", \"start_char\": 0, \"end_char\": 1849, \"text_sha256\": \"d96a112b2d48544349cd136e7078ac9cdac3ecbedb41f2983db742b36e1cd8a9\"}\n[lycopene-p24911964] Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. 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