Component
Human FLVCR1 / SLC49A1
Human FLVCR1 / SLC49A1. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human FLVCR1 facilitated concentration-driven choline transport across the plasma membrane.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/38778100.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4", "start_char": 0, "end_char": 1367, "text_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4"}
- experimental_model
- Human transporter expression, uptake, cryo-EM and mutagenesis
- exposure
- Choline/ethanolamine substrate challenges and purified transporter structures
- limitations
- Concentration-driven transport in these preparations; not proof that a single transporter supplies every tissue. Historical heme assignments are not copied as established choline mechanisms.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human proteins in experimental systems
- plain_language
- FLVCR1 can move choline across the cell boundary.
- primary_references
- [choline-p38778100] Molecular mechanism of choline and ethanolamine transport in humans. (2024). https://pubmed.ncbi.nlm.nih.gov/38778100/ DOI: 10.1038/s41586-024-07444-7
- tissue_or_cell_type
- Plasma-membrane transport
- transport_effect
- depends Recorded as concentration-driven transport, so the net direction follows the gradient.
- transport_pool
- the cytosol across the plasma membrane Recorded as concentration-driven transport, so the net direction follows the gradient.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 217–228
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human transporter expression, uptake, cryo-EM and mutagenesis · source_derived_draft · unverified_draft
### choline-flvcr1-choline Human FLVCR1 facilitated concentration-driven choline transport across the plasma membrane. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: FLVCR1 can move choline across the cell boundary. organism: Human proteins in experimental systems tissue_or_cell_type: Plasma-membrane transport experimental_model: Human transporter expression, uptake, cryo-EM and mutagenesis limitations: Concentration-driven transport in these preparations; not proof that a single transporter supplies every tissue. Historical heme assignments are not copied as established choline mechanisms. exposure: Choline/ethanolamine substrate challenges and purified transporter structures evidence_span: {"source_cache": "artifacts/choline-research/38778100.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4", "start_char": 0, "end_char": 1367, "text_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4"} [choline-p38778100] Molecular mechanism of choline and ethanolamine transport in humans. (2024). https://pubmed.ncbi.nlm.nih.gov/38778100/ DOI: 10.1038/s41586-024-07444-7
Complete structured claim and evidenceHuman FLVCR1 facilitated concentration-driven ethanolamine transport across the plasma membrane.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/38778100.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4", "start_char": 0, "end_char": 1367, "text_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4"}
- experimental_model
- Human transporter expression, uptake, cryo-EM and mutagenesis
- exposure
- Choline/ethanolamine substrate challenges and purified transporter structures
- limitations
- Concentration-driven transport in these preparations; not proof that a single transporter supplies every tissue. Historical heme assignments are not copied as established choline mechanisms.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human proteins in experimental systems
- plain_language
- FLVCR1 can move ethanolamine across the cell boundary.
- primary_references
- [choline-p38778100] Molecular mechanism of choline and ethanolamine transport in humans. (2024). https://pubmed.ncbi.nlm.nih.gov/38778100/ DOI: 10.1038/s41586-024-07444-7
- tissue_or_cell_type
- Plasma-membrane transport
- transport_effect
- depends Recorded as concentration-driven transport, so the net direction follows the gradient.
- transport_pool
- the cytosol across the plasma membrane Recorded as concentration-driven transport, so the net direction follows the gradient.
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 230–241
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human transporter expression, uptake, cryo-EM and mutagenesis · source_derived_draft · unverified_draft
### choline-flvcr1-ethanolamine Human FLVCR1 facilitated concentration-driven ethanolamine transport across the plasma membrane. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: FLVCR1 can move ethanolamine across the cell boundary. organism: Human proteins in experimental systems tissue_or_cell_type: Plasma-membrane transport experimental_model: Human transporter expression, uptake, cryo-EM and mutagenesis limitations: Concentration-driven transport in these preparations; not proof that a single transporter supplies every tissue. Historical heme assignments are not copied as established choline mechanisms. exposure: Choline/ethanolamine substrate challenges and purified transporter structures evidence_span: {"source_cache": "artifacts/choline-research/38778100.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4", "start_char": 0, "end_char": 1367, "text_sha256": "0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4"} [choline-p38778100] Molecular mechanism of choline and ethanolamine transport in humans. (2024). https://pubmed.ncbi.nlm.nih.gov/38778100/ DOI: 10.1038/s41586-024-07444-7
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.