{"id":"a4f7052b-3d2b-58a1-8a66-af952d1991fb","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-flvcr1-ethanolamine","predicate":"transports","statement":"Human FLVCR1 facilitated concentration-driven ethanolamine transport across the plasma membrane.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"eb4c4e38-c18a-5b35-89bf-f708b2bea44e","mechanism_event_label":"FLVCR1 can move ethanolamine across the cell boundary.","subject":{"id":"de729a75-5629-5881-8bd5-c0f7fd6f34ea","slug":"flvcr1","display_name":"Human FLVCR1 / SLC49A1","entity_type_key":"protein"},"object":{"id":"e043e93c-02dd-5de1-af50-54fefe5b7643","slug":"ethanolamine","display_name":"Ethanolamine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"eb4c4e38-c18a-5b35-89bf-f708b2bea44e","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-flvcr1-ethanolamine-event","event_type":"biochemical_relationship","label":"FLVCR1 can move ethanolamine across the cell boundary.","description":"Human FLVCR1 facilitated concentration-driven ethanolamine transport across the plasma membrane.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"de729a75-5629-5881-8bd5-c0f7fd6f34ea","slug":"flvcr1","display_name":"Human FLVCR1 / SLC49A1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e043e93c-02dd-5de1-af50-54fefe5b7643","slug":"ethanolamine","display_name":"Ethanolamine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/38778100.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4\", \"start_char\": 0, \"end_char\": 1367, \"text_sha256\": \"0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human transporter expression, uptake, cryo-EM and mutagenesis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Choline/ethanolamine substrate challenges and purified transporter structures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Concentration-driven transport in these preparations; not proof that a single transporter supplies every tissue. 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Historical heme assignments are not copied as established choline mechanisms.\nexposure: Choline/ethanolamine substrate challenges and purified transporter structures\nevidence_span: {\"source_cache\": \"artifacts/choline-research/38778100.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4\", \"start_char\": 0, \"end_char\": 1367, \"text_sha256\": \"0c0c95f81ece7f339f1b92631ced5244c053d1b4a4cbfd9ef964ff0640b5aed4\"}\n[choline-p38778100] Molecular mechanism of choline and ethanolamine transport in humans. (2024). https://pubmed.ncbi.nlm.nih.gov/38778100/ DOI: 10.1038/s41586-024-07444-7","model_system":"Human transporter expression, uptake, cryo-EM and mutagenesis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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