Component
Human filaggrin / FLG
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Adding L-histidine increased filaggrin monomer formation in the reported human keratinocyte/skin-equivalent experiments.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Human keratinocyte differentiation and skin-equivalent models.
- limitations
- Culture response does not prove all eczema reflects histidine shortage or that FLG null variants can be repaired; one author was a director of a patent-owning company.
- nutrient_topic
- L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Histidine
- plain_language
- More available substrate changed a skin-protein processing readout in culture.
- primary_references
- Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29042806/ · DOI 10.2147/CCID.S146760
L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19) · lines 410–416
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human keratinocyte differentiation and skin-equivalent models. · source_derived_draft · unverified_draft
## histidine-skin-flg-processing More available substrate changed a skin-protein processing readout in culture. Adding L-histidine increased filaggrin monomer formation in the reported human keratinocyte/skin-equivalent experiments. Model: Human keratinocyte differentiation and skin-equivalent models. Limitations: Culture response does not prove all eczema reflects histidine shortage or that FLG null variants can be repaired; one author was a director of a patent-owning company. Evidence access: Primary full text Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29042806/ · DOI 10.2147/CCID.S146760
Complete structured claim and evidence
Where it participates (unsigned role)
Histidine supplementation improved the measured barrier readout in human skin-equivalent experiments.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Human skin-equivalent in-vitro assay.
- limitations
- Separate from oral clinical outcomes; no direct proof of the entire mediation chain in patients.
- nutrient_topic
- L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Histidine
- plain_language
- The culture study also measured a functional barrier outcome.
- primary_references
- Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29042806/ · DOI 10.2147/CCID.S146760
L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19) · lines 418–424
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human skin-equivalent in-vitro assay. · source_derived_draft · unverified_draft
## histidine-skin-barrier The culture study also measured a functional barrier outcome. Histidine supplementation improved the measured barrier readout in human skin-equivalent experiments. Model: Human skin-equivalent in-vitro assay. Limitations: Separate from oral clinical outcomes; no direct proof of the entire mediation chain in patients. Evidence access: Primary full text Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29042806/ · DOI 10.2147/CCID.S146760
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.