Component
Gastric first-pass metabolism of ethanol
Gastric first-pass metabolism of ethanol. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Human gastric alcohol dehydrogenase activity varied with age, sex and alcoholism in biopsy material.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/8244116.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de", "start_char": 0, "end_char": 1985, "text_sha256": "69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de"}
- experimental_model
- Gastric biopsy alcohol dehydrogenase activity across age, sex and alcoholism
- exposure
- Measured enzyme activity in biopsy material
- limitations
- A larger observational series of the same enzyme. It reports how the activity varies, not what that variation causes.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Human
- plain_language
- The size of the stomach barrier is not the same in everyone.
- primary_references
- [alcohol-p8244116] Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism. (1993). https://pubmed.ncbi.nlm.nih.gov/8244116/ DOI: 10.1136/gut.34.10.1433
- tissue_or_cell_type
- Gastric mucosa
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 215–226
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Gastric biopsy alcohol dehydrogenase activity across age, sex and alcoholism · source_derived_draft · unverified_draft
### alcohol-gastric-adh-varies Human gastric alcohol dehydrogenase activity varied with age, sex and alcoholism in biopsy material. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The size of the stomach barrier is not the same in everyone. organism: Human tissue_or_cell_type: Gastric mucosa experimental_model: Gastric biopsy alcohol dehydrogenase activity across age, sex and alcoholism limitations: A larger observational series of the same enzyme. It reports how the activity varies, not what that variation causes. exposure: Measured enzyme activity in biopsy material evidence_span: {"source_cache": "artifacts/alcohol-research/8244116.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de", "start_char": 0, "end_char": 1985, "text_sha256": "69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de"} [alcohol-p8244116] Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism. (1993). https://pubmed.ncbi.nlm.nih.gov/8244116/ DOI: 10.1136/gut.34.10.1433
Complete structured claim and evidence
Where it participates (unsigned role)
Decreased gastric alcohol dehydrogenase activity and decreased first-pass metabolism accounted for higher blood alcohol levels in women given the same oral dose.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/2248624.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8679c8360907919917314956d4febe0010e0e35619c2032360341f4964a3e16", "start_char": 0, "end_char": 1624, "text_sha256": "e8679c8360907919917314956d4febe0010e0e35619c2032360341f4964a3e16"}
- experimental_model
- Blood alcohol and gastric biopsy alcohol dehydrogenase activity in men and women
- exposure
- Oral versus intravenous ethanol, with gastric biopsy enzyme assay
- limitations
- The oral versus intravenous comparison is what isolates first-pass metabolism. Sample sizes are small and the effect size has been debated since.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Human
- plain_language
- Some alcohol is destroyed in the stomach wall before it reaches the blood, and that barrier is smaller in women.
- primary_references
- [alcohol-p2248624] High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. (1990). https://pubmed.ncbi.nlm.nih.gov/2248624/ DOI: 10.1056/nejm199001113220205
- tissue_or_cell_type
- Gastric mucosa
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 202–213
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Blood alcohol and gastric biopsy alcohol dehydrogenase activity in men and women · source_derived_draft · unverified_draft
### alcohol-gastric-first-pass Decreased gastric alcohol dehydrogenase activity and decreased first-pass metabolism accounted for higher blood alcohol levels in women given the same oral dose. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: Some alcohol is destroyed in the stomach wall before it reaches the blood, and that barrier is smaller in women. organism: Human tissue_or_cell_type: Gastric mucosa experimental_model: Blood alcohol and gastric biopsy alcohol dehydrogenase activity in men and women limitations: The oral versus intravenous comparison is what isolates first-pass metabolism. Sample sizes are small and the effect size has been debated since. exposure: Oral versus intravenous ethanol, with gastric biopsy enzyme assay evidence_span: {"source_cache": "artifacts/alcohol-research/2248624.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8679c8360907919917314956d4febe0010e0e35619c2032360341f4964a3e16", "start_char": 0, "end_char": 1624, "text_sha256": "e8679c8360907919917314956d4febe0010e0e35619c2032360341f4964a3e16"} [alcohol-p2248624] High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. (1990). https://pubmed.ncbi.nlm.nih.gov/2248624/ DOI: 10.1056/nejm199001113220205
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.