{"id":"a2d7f663-dcbe-55ae-9dc6-7725d8319394","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-gastric-adh-varies","predicate":"modulates","statement":"Human gastric alcohol dehydrogenase activity varied with age, sex and alcoholism in biopsy material.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"960f2cda-38fb-5ce4-94ef-6979d0f910a1","mechanism_event_label":"The size of the stomach barrier is not the same in everyone.","subject":{"id":"44ffa5c2-9149-5bd4-b4d4-76fbafd7eb9a","slug":"gastric-adh","display_name":"Gastric mucosal alcohol dehydrogenase activity","entity_type_key":"cellular_process"},"object":{"id":"3de2776e-7299-5e31-966a-0f7e1c64c2b7","slug":"first-pass-ethanol-metabolism","display_name":"Gastric first-pass metabolism of ethanol","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"960f2cda-38fb-5ce4-94ef-6979d0f910a1","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-gastric-adh-varies-event","event_type":"observed_intervention","label":"The size of the stomach barrier is not the same in everyone.","description":"Human gastric alcohol dehydrogenase activity varied with age, sex and alcoholism in biopsy material.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"44ffa5c2-9149-5bd4-b4d4-76fbafd7eb9a","slug":"gastric-adh","display_name":"Gastric mucosal alcohol dehydrogenase activity","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3de2776e-7299-5e31-966a-0f7e1c64c2b7","slug":"first-pass-ethanol-metabolism","display_name":"Gastric first-pass metabolism of ethanol","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/8244116.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de\", \"start_char\": 0, \"end_char\": 1985, \"text_sha256\": \"69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Gastric biopsy alcohol dehydrogenase activity across age, sex and alcoholism","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Measured enzyme activity in biopsy material","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A larger observational series of the same enzyme. It reports how the activity varies, not what that variation causes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The size of the stomach barrier is not the same in everyone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p8244116] Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism. (1993). https://pubmed.ncbi.nlm.nih.gov/8244116/ DOI: 10.1136/gut.34.10.1433","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Gastric mucosa","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7f0d3877-7a06-5f25-ba76-151d42cb34b8","evidence_kind":"source_excerpt","locator":"Lines 215-226","start_line":215,"end_line":226,"excerpt":"### alcohol-gastric-adh-varies\nHuman gastric alcohol dehydrogenase activity varied with age, sex and alcoholism in biopsy material.\nCondition category: normal\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: The size of the stomach barrier is not the same in everyone.\norganism: Human\ntissue_or_cell_type: Gastric mucosa\nexperimental_model: Gastric biopsy alcohol dehydrogenase activity across age, sex and alcoholism\nlimitations: A larger observational series of the same enzyme. It reports how the activity varies, not what that variation causes.\nexposure: Measured enzyme activity in biopsy material\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/8244116.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de\", \"start_char\": 0, \"end_char\": 1985, \"text_sha256\": \"69408eea35e836f0be82630ffd1e713af36a3224f9fc2a87f9f14411d32ab4de\"}\n[alcohol-p8244116] Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism. (1993). https://pubmed.ncbi.nlm.nih.gov/8244116/ DOI: 10.1136/gut.34.10.1433","model_system":"Gastric biopsy alcohol dehydrogenase activity across age, sex and alcoholism","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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