Component

Ferrous succinate

Independent measured endpoint or substance; model, assay and exposure are retained in each linked finding.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Eight-week ferritin increases were 35.75 versus 34.48 ng/mL; between-group difference 1.27 (95% CI -0.70 to 3.24; P=0.21).

    L-Ascorbic acid → Serum ferritin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Vitamin C/iron clinical outcome recorded separately from the uptake reaction.
    experimental_model
    Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.
    exposure
    Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron.
    limitations
    Ferritin is a biomarker; no proof that iron absorption was identical at every meal.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    The added vitamin C did not significantly improve the measured iron-storage response.
    primary_references
    [c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644
    tissue_or_cell_type
    Human blood or whole-person endpoints
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1632–1643

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women. · source_derived_draft · unverified_draft

    ### c-iron-treatment-ferritin-null Eight-week ferritin increases were 35.75 versus 34.48 ng/mL; between-group difference 1.27 (95% CI -0.70 to 3.24; P=0.21). Condition category: nutrient_deficiency nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The added vitamin C did not significantly improve the measured iron-storage response. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women. limitations: Ferritin is a biomarker; no proof that iron absorption was identical at every meal. exposure: Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron. cross_nutrient: Vitamin C/iron clinical outcome recorded separately from the uptake reaction. [c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644
    Complete structured claim and evidence

  2. Hemoglobin increased 2.00 g/dL with iron plus C versus 1.84 with iron alone at two weeks; difference 0.16 (95% CI -0.03 to 0.35), within the prespecified 1-g/dL equivalence margin.

    L-Ascorbic acid → Blood hemoglobin concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Separates chemical absorption support from added clinical benefit during iron replacement.
    experimental_model
    Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.
    exposure
    Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron.
    limitations
    Equivalence is margin-dependent and does not mean numerical identity; no direct isotope absorption or intracellular mechanism was measured.
    nutrient_topic
    Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
    organism
    Homo sapiens
    plain_language
    Adding vitamin C did not provide a clinically distinct early hemoglobin response under the trial’s equivalence definition.
    primary_references
    [c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644
    tissue_or_cell_type
    Human blood or whole-person endpoints
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1619–1630

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women. · source_derived_draft · unverified_draft

    ### c-iron-treatment-hemoglobin-equivalence Hemoglobin increased 2.00 g/dL with iron plus C versus 1.84 with iron alone at two weeks; difference 0.16 (95% CI -0.03 to 0.35), within the prespecified 1-g/dL equivalence margin. Condition category: nutrient_deficiency nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Adding vitamin C did not provide a clinically distinct early hemoglobin response under the trial’s equivalence definition. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women. limitations: Equivalence is margin-dependent and does not mean numerical identity; no direct isotope absorption or intracellular mechanism was measured. exposure: Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron. cross_nutrient: Separates chemical absorption support from added clinical benefit during iron replacement. [c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards