{"id":"0fccb0af-555e-5749-a7cd-cb837fc3f628","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-iron-treatment-hemoglobin-equivalence","predicate":"addition_to_iron_met_hemoglobin_equivalence_margin","statement":"Hemoglobin increased 2.00 g/dL with iron plus C versus 1.84 with iron alone at two weeks; difference 0.16 (95% CI -0.03 to 0.35), within the prespecified 1-g/dL equivalence margin.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"691392d1-03b2-55aa-a838-3fb4355b497a","mechanism_event_label":"Adding vitamin C did not provide a clinically distinct early hemoglobin response under the trial’s equivalence definition.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"2f3a8d0b-7b92-58d2-afc9-dd26a7cd1e0e","slug":"blood-hemoglobin-concentration","display_name":"Blood hemoglobin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"691392d1-03b2-55aa-a838-3fb4355b497a","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-iron-treatment-hemoglobin-equivalence-event","event_type":"observed_intervention","label":"Adding vitamin C did not provide a clinically distinct early hemoglobin response under the trial’s equivalence definition.","description":"Hemoglobin increased 2.00 g/dL with iron plus C versus 1.84 with iron alone at two weeks; difference 0.16 (95% CI -0.03 to 0.35), within the prespecified 1-g/dL equivalence margin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"57ad57d6-e05b-522a-a5d5-fa6e6ad923ae","slug":"ferrous-succinate","display_name":"Ferrous succinate","entity_type_key":"small_molecule"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"deficient_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2f3a8d0b-7b92-58d2-afc9-dd26a7cd1e0e","slug":"blood-hemoglobin-concentration","display_name":"Blood hemoglobin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Separates chemical absorption support from added clinical benefit during iron replacement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Equivalence is margin-dependent and does not mean numerical identity; no direct isotope absorption or intracellular mechanism was measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding vitamin C did not provide a clinically distinct early hemoglobin response under the trial’s equivalence definition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d21274f8-9358-5677-80eb-f25104c98e5e","evidence_kind":"source_excerpt","locator":"Lines 1619-1630","start_line":1619,"end_line":1630,"excerpt":"### c-iron-treatment-hemoglobin-equivalence\nHemoglobin increased 2.00 g/dL with iron plus C versus 1.84 with iron alone at two weeks; difference 0.16 (95% CI -0.03 to 0.35), within the prespecified 1-g/dL equivalence margin.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Adding vitamin C did not provide a clinically distinct early hemoglobin response under the trial’s equivalence definition.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.\nlimitations: Equivalence is margin-dependent and does not mean numerical identity; no direct isotope absorption or intracellular mechanism was measured.\nexposure: Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron.\ncross_nutrient: Separates chemical absorption support from added clinical benefit during iron replacement.\n[c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644","model_system":"Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}