{"id":"49940e9e-385a-5486-bcff-1da415bf60c1","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-iron-treatment-ferritin-null","predicate":"addition_to_iron_did_not_significantly_improve_ferritin_change","statement":"Eight-week ferritin increases were 35.75 versus 34.48 ng/mL; between-group difference 1.27 (95% CI -0.70 to 3.24; P=0.21).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"39af6790-52df-5842-95be-08cd3a3e7bac","mechanism_event_label":"The added vitamin C did not significantly improve the measured iron-storage response.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"9b302959-20f9-5764-9635-793e8435e278","slug":"serum-ferritin-concentration","display_name":"Serum ferritin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"39af6790-52df-5842-95be-08cd3a3e7bac","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-iron-treatment-ferritin-null-event","event_type":"observed_intervention","label":"The added vitamin C did not significantly improve the measured iron-storage response.","description":"Eight-week ferritin increases were 35.75 versus 34.48 ng/mL; between-group difference 1.27 (95% CI -0.70 to 3.24; P=0.21).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"57ad57d6-e05b-522a-a5d5-fa6e6ad923ae","slug":"ferrous-succinate","display_name":"Ferrous succinate","entity_type_key":"small_molecule"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"deficient_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9b302959-20f9-5764-9635-793e8435e278","slug":"serum-ferritin-concentration","display_name":"Serum ferritin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Vitamin C/iron clinical outcome recorded separately from the uptake reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ferritin is a biomarker; no proof that iron absorption was identical at every meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The added vitamin C did not significantly improve the measured iron-storage response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a4de87ae-072d-55b6-945c-a2a1f60baee8","evidence_kind":"source_excerpt","locator":"Lines 1632-1643","start_line":1632,"end_line":1643,"excerpt":"### c-iron-treatment-ferritin-null\nEight-week ferritin increases were 35.75 versus 34.48 ng/mL; between-group difference 1.27 (95% CI -0.70 to 3.24; P=0.21).\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The added vitamin C did not significantly improve the measured iron-storage response.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.\nlimitations: Ferritin is a biomarker; no proof that iron absorption was identical at every meal.\nexposure: Ferrous succinate 100 mg/tablet with or without vitamin C 200 mg every eight hours, three months; taken half an hour after meals. Tablet mass is not relabeled as elemental iron.\ncross_nutrient: Vitamin C/iron clinical outcome recorded separately from the uptake reaction.\n[c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644","model_system":"Single-center open-label randomized equivalence trial: 440 adults with iron-deficiency anemia, 426 women.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-li2020] The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial (2020). https://pubmed.ncbi.nlm.nih.gov/33136134/ DOI: 10.1001/jamanetworkopen.2020.23644","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}