A meal containing fat, taken with the dose: molecular mechanisms & dependencies

How nutrients influence it

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Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

When 1.5 gram doses were given to three volunteers, measurable plasma concentrations of 17 to 134 nanomoles per litre were found only if mebendazole was given together with a fatty meal, in a patient with cholestasis plasma concentrations were higher than in the three normal subjects, and in patients on long-term treatment the increase in plasma concentration after a 1 gram dose varied between 0 and 500 nanomoles per litre, so that monitoring plasma levels during long-term therapy appears advisable.
A meal containing fat, taken with the dose → Plasma concentration of mebendazole source_derived_draftungraded
Experimental context and source evidence
availability_state
biomarker_context Imported condition classification; unverified.
evidence_span
{"source_cache": "artifacts/mebendazole-research/7418715.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b3e200ec505a4a58edacfcf8a51f1073d528d8fc7718fd5cd10a6ca15cbded10", "start_char": 0, "end_char": 812, "text_sha256": "b3e200ec505a4a58edacfcf8a51f1073d528d8fc7718fd5cd10a6ca15cbded10"}
experimental_model
Plasma concentrations in three volunteers given 1.5 gram doses and in patients on long-term treatment
exposure
1.5 gram oral doses given with and without a fatty meal
limitations
Three volunteers. The finding that concentrations were measurable only with food is the substantive result; the cholestasis observation is a single patient.
nutrient_topic
Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
organism
Human
plain_language
Without fat in the meal the drug does not reach the blood at all, and between patients the levels vary from nothing to a great deal.
primary_references
[mbz-p7418715] Plasma concentrations of mebendazole during treatment of echinococcosis: preliminary results. (1980). https://pubmed.ncbi.nlm.nih.gov/7418715/ DOI: 10.1007/bf00558451
tissue_or_cell_type
Plasma
trigger_kind
biomarker_context Imported condition classification; unverified.
Mebendazole: the tubulin it binds, why that is selective, the crystal form that decides whether any of it works, and the off-target that became an oncology programme (2026-09-22) · lines 420–431
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Plasma concentrations in three volunteers given 1.5 gram doses and in patients on long-term treatment · source_derived_draft · unverified_draft
### mbz-food-is-required When 1.5 gram doses were given to three volunteers, measurable plasma concentrations of 17 to 134 nanomoles per litre were found only if mebendazole was given together with a fatty meal, in a patient with cholestasis plasma concentrations were higher than in the three normal subjects, and in patients on long-term treatment the increase in plasma concentration after a 1 gram dose varied between 0 and 500 nanomoles per litre, so that monitoring plasma levels during long-term therapy appears advisable. Condition category: biomarker_context nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: Without fat in the meal the drug does not reach the blood at all, and between patients the levels vary from nothing to a great deal. organism: Human tissue_or_cell_type: Plasma experimental_model: Plasma concentrations in three volunteers given 1.5 gram doses and in patients on long-term treatment limitations: Three volunteers. The finding that concentrations were measurable only with food is the substantive result; the cholestasis observation is a single patient. exposure: 1.5 gram oral doses given with and without a fatty meal evidence_span: {"source_cache": "artifacts/mebendazole-research/7418715.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b3e200ec505a4a58edacfcf8a51f1073d528d8fc7718fd5cd10a6ca15cbded10", "start_char": 0, "end_char": 812, "text_sha256": "b3e200ec505a4a58edacfcf8a51f1073d528d8fc7718fd5cd10a6ca15cbded10"} [mbz-p7418715] Plasma concentrations of mebendazole during treatment of echinococcosis: preliminary results. (1980). https://pubmed.ncbi.nlm.nih.gov/7418715/ DOI: 10.1007/bf00558451
Complete structured claim and evidence

Where it participates (unsigned role)

Absorption of oral flubendazole in man was markedly enhanced when the drug was taken together with a meal, but a twenty times higher dose produced only an increase by a factor of 1.4 in plasma levels and area under the curve, indicating that absorption is limited by the extremely poor solubility of the drug in the contents of the gastrointestinal tract; in rats plasma levels of oral and subcutaneous mebendazole were about ten times higher than those of flubendazole.
Flubendazole → Oral bioavailability source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/mebendazole-research/7103610.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0", "start_char": 0, "end_char": 948, "text_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0"}
experimental_model
Radioimmunoassay of mebendazole and flubendazole across rats, dogs and man
exposure
Oral, subcutaneous and intramuscular dosing, and a twentyfold oral dose escalation of flubendazole in man
limitations
The dose-escalation arm is about flubendazole rather than mebendazole, and is recorded under flubendazole; it is retained because it demonstrates the solubility limit that governs this whole class.
nutrient_topic
Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
organism
Rat, dog and human
plain_language
Twenty times the dose gave less than half again as much in the blood, because it simply will not dissolve.
primary_references
[mbz-p7103610] The pharmacokinetics of mebendazole and flubendazole in animals and man. (1982). https://pubmed.ncbi.nlm.nih.gov/7103610/
tissue_or_cell_type
Plasma
Mebendazole: the tubulin it binds, why that is selective, the crystal form that decides whether any of it works, and the off-target that became an oncology programme (2026-09-22) · lines 459–470
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radioimmunoassay of mebendazole and flubendazole across rats, dogs and man · source_derived_draft · unverified_draft
### mbz-dose-escalation-fails Absorption of oral flubendazole in man was markedly enhanced when the drug was taken together with a meal, but a twenty times higher dose produced only an increase by a factor of 1.4 in plasma levels and area under the curve, indicating that absorption is limited by the extremely poor solubility of the drug in the contents of the gastrointestinal tract; in rats plasma levels of oral and subcutaneous mebendazole were about ten times higher than those of flubendazole. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: Twenty times the dose gave less than half again as much in the blood, because it simply will not dissolve. organism: Rat, dog and human tissue_or_cell_type: Plasma experimental_model: Radioimmunoassay of mebendazole and flubendazole across rats, dogs and man limitations: The dose-escalation arm is about flubendazole rather than mebendazole, and is recorded under flubendazole; it is retained because it demonstrates the solubility limit that governs this whole class. exposure: Oral, subcutaneous and intramuscular dosing, and a twentyfold oral dose escalation of flubendazole in man evidence_span: {"source_cache": "artifacts/mebendazole-research/7103610.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0", "start_char": 0, "end_char": 948, "text_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0"} [mbz-p7103610] The pharmacokinetics of mebendazole and flubendazole in animals and man. (1982). https://pubmed.ncbi.nlm.nih.gov/7103610/
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

A meal containing fat, taken with the dose