Component
Flubendazole
Flubendazole. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Absorption of oral flubendazole in man was markedly enhanced when the drug was taken together with a meal, but a twenty times higher dose produced only an increase by a factor of 1.4 in plasma levels and area under the curve, indicating that absorption is limited by the extremely poor solubility of the drug in the contents of the gastrointestinal tract; in rats plasma levels of oral and subcutaneous mebendazole were about ten times higher than those of flubendazole.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mebendazole-research/7103610.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0", "start_char": 0, "end_char": 948, "text_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0"}
- experimental_model
- Radioimmunoassay of mebendazole and flubendazole across rats, dogs and man
- exposure
- Oral, subcutaneous and intramuscular dosing, and a twentyfold oral dose escalation of flubendazole in man
- limitations
- The dose-escalation arm is about flubendazole rather than mebendazole, and is recorded under flubendazole; it is retained because it demonstrates the solubility limit that governs this whole class.
- nutrient_topic
- Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
- organism
- Rat, dog and human
- plain_language
- Twenty times the dose gave less than half again as much in the blood, because it simply will not dissolve.
- primary_references
- [mbz-p7103610] The pharmacokinetics of mebendazole and flubendazole in animals and man. (1982). https://pubmed.ncbi.nlm.nih.gov/7103610/
- tissue_or_cell_type
- Plasma
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radioimmunoassay of mebendazole and flubendazole across rats, dogs and man · source_derived_draft · unverified_draft
### mbz-dose-escalation-fails Absorption of oral flubendazole in man was markedly enhanced when the drug was taken together with a meal, but a twenty times higher dose produced only an increase by a factor of 1.4 in plasma levels and area under the curve, indicating that absorption is limited by the extremely poor solubility of the drug in the contents of the gastrointestinal tract; in rats plasma levels of oral and subcutaneous mebendazole were about ten times higher than those of flubendazole. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: Twenty times the dose gave less than half again as much in the blood, because it simply will not dissolve. organism: Rat, dog and human tissue_or_cell_type: Plasma experimental_model: Radioimmunoassay of mebendazole and flubendazole across rats, dogs and man limitations: The dose-escalation arm is about flubendazole rather than mebendazole, and is recorded under flubendazole; it is retained because it demonstrates the solubility limit that governs this whole class. exposure: Oral, subcutaneous and intramuscular dosing, and a twentyfold oral dose escalation of flubendazole in man evidence_span: {"source_cache": "artifacts/mebendazole-research/7103610.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0", "start_char": 0, "end_char": 948, "text_sha256": "e582dcb4657e254dfe61d437d899b2db4d2a4628aa1267fb90de6366b7b4c8f0"} [mbz-p7103610] The pharmacokinetics of mebendazole and flubendazole in animals and man. (1982). https://pubmed.ncbi.nlm.nih.gov/7103610/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.