Component
Lower intestinal adenoma count in familial adenomatous polyposis
Lower intestinal adenoma count in familial adenomatous polyposis. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The randomized study found no significant difference in mean adenoma count between curcumin and placebo.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/29802852.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44", "start_char": 0, "end_char": 2094, "text_sha256": "d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44"}
- experimental_model
- Double-blind randomized placebo-controlled trial in 44 FAP patients
- exposure
- Purified curcumin 1500 mg twice/day; protocol described as 12 months
- limitations
- The indexed abstract inconsistently says 12 weeks in results/conclusion despite 12-month methods; no precise endpoint duration is assigned to the result below. No inference of cancer prevention.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Homo sapiens
- plain_language
- The trial did not confirm a reduction in the number of polyps.
- primary_references
- [curcumin-p29802852] Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis. (2018). https://pubmed.ncbi.nlm.nih.gov/29802852/ DOI: 10.1053/j.gastro.2018.05.031
- tissue_or_cell_type
- Lower intestinal adenomas
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1061–1072
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized placebo-controlled trial in 44 FAP patients · source_derived_draft · unverified_draft
### curcumin-fap-count-null The randomized study found no significant difference in mean adenoma count between curcumin and placebo. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The trial did not confirm a reduction in the number of polyps. organism: Homo sapiens tissue_or_cell_type: Lower intestinal adenomas experimental_model: Double-blind randomized placebo-controlled trial in 44 FAP patients limitations: The indexed abstract inconsistently says 12 weeks in results/conclusion despite 12-month methods; no precise endpoint duration is assigned to the result below. No inference of cancer prevention. exposure: Purified curcumin 1500 mg twice/day; protocol described as 12 months evidence_span: {"source_cache": "artifacts/curcumin-research/29802852.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44", "start_char": 0, "end_char": 2094, "text_sha256": "d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44"} [curcumin-p29802852] Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis. (2018). https://pubmed.ncbi.nlm.nih.gov/29802852/ DOI: 10.1053/j.gastro.2018.05.031
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.