{"id":"96f7ecf2-2008-508f-bafa-eddcca2f751d","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-fap-count-null","predicate":"did_not_significantly_reduce","statement":"The randomized study found no significant difference in mean adenoma count between curcumin and placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43f7ea94-8d4c-586b-8343-1f829db7b26b","mechanism_event_label":"The trial did not confirm a reduction in the number of polyps.","subject":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"object":{"id":"3b6b6ceb-057e-5cdf-b63d-a5c0c77e1966","slug":"fap-polyp-number","display_name":"Lower intestinal adenoma count in familial adenomatous polyposis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43f7ea94-8d4c-586b-8343-1f829db7b26b","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-fap-count-null-event","event_type":"observed_intervention","label":"The trial did not confirm a reduction in the number of polyps.","description":"The randomized study found no significant difference in mean adenoma count between curcumin and placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3b6b6ceb-057e-5cdf-b63d-a5c0c77e1966","slug":"fap-polyp-number","display_name":"Lower intestinal adenoma count in familial adenomatous polyposis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/29802852.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44\", \"start_char\": 0, \"end_char\": 2094, \"text_sha256\": \"d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized placebo-controlled trial in 44 FAP patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Purified curcumin 1500 mg twice/day; protocol described as 12 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The indexed abstract inconsistently says 12 weeks in results/conclusion despite 12-month methods; no precise endpoint duration is assigned to the result below. 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(2018). https://pubmed.ncbi.nlm.nih.gov/29802852/ DOI: 10.1053/j.gastro.2018.05.031","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Lower intestinal adenomas","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e13c5c48-72ce-5ea9-a7cc-46ecac3c843d","evidence_kind":"source_excerpt","locator":"Lines 1061-1072","start_line":1061,"end_line":1072,"excerpt":"### curcumin-fap-count-null\nThe randomized study found no significant difference in mean adenoma count between curcumin and placebo.\nCondition category: normal\nnutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial did not confirm a reduction in the number of polyps.\norganism: Homo sapiens\ntissue_or_cell_type: Lower intestinal adenomas\nexperimental_model: Double-blind randomized placebo-controlled trial in 44 FAP patients\nlimitations: The indexed abstract inconsistently says 12 weeks in results/conclusion despite 12-month methods; no precise endpoint duration is assigned to the result below. No inference of cancer prevention.\nexposure: Purified curcumin 1500 mg twice/day; protocol described as 12 months\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/29802852.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44\", \"start_char\": 0, \"end_char\": 2094, \"text_sha256\": \"d9f3bba0ad0cc2b24e75d102e678b2c92867808bcb5181ee1da8ceae0d71ad44\"}\n[curcumin-p29802852] Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis. (2018). https://pubmed.ncbi.nlm.nih.gov/29802852/ DOI: 10.1053/j.gastro.2018.05.031","model_system":"Double-blind randomized placebo-controlled trial in 44 FAP patients","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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