Component

Human coagulation factor VIII / F8

Intrinsic-pathway cofactor.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Factor VIII activity declined significantly at 4 and 6 h after the same single dose.

    NSK-SD fermented soybean extract → Human coagulation factor VIII / F8 source_derived_draftungraded
    Experimental context and source evidence
    duration
    Single dose, sampling to 8 h
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    Human (12 healthy young males)
    exposure
    NSK-SD, 2,000 FU single dose
    limitations
    Within the normal range. No direct proteolytic cleavage of factor VIII by purified nattokinase has been shown anywhere in the retrieved evidence, so the step producing this is unidentified.
    organism
    Human (12 healthy young males)
    plain_language
    Factor VIII activity declined significantly at 4 and 6 h after the same single dose.
    primary_references
    A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. (2015) https://pubmed.ncbi.nlm.nih.gov/26109079/ DOI: 10.1038/srep11601
    route
    In vivo, oral
    tissue
    Plasma

    Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23) · lines 873–873

    Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text. · supports · Human (12 healthy young males) · source_derived_draft · unverified_draft

    Factor VIII activity declined significantly at 4 and 6 h after the same single dose.
    Complete structured claim and evidence

  2. Factor VIII declined by 17 to 19% over the same two months.

    Commercial nattokinase supplement, composition study-specific → Human coagulation factor VIII / F8 source_derived_draftungraded
    Experimental context and source evidence
    duration
    2 months
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    Human (45 subjects across three groups)
    exposure
    Nattokinase, 4,000 FU per day
    limitations
    As above, and the largest of the three declines. It agrees in direction with the single-dose crossover result, which is a different design in a different population.
    organism
    Human (45 subjects across three groups)
    plain_language
    Factor VIII declined by 17 to 19% over the same two months.
    primary_references
    Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. (2009) https://pubmed.ncbi.nlm.nih.gov/19358933/ DOI: 10.1016/j.nutres.2009.01.009
    route
    In vivo, oral
    tissue
    Plasma

    Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23) · lines 939–939

    Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text. · supports · Human (45 subjects across three groups) · source_derived_draft · unverified_draft

    Factor VIII declined by 17 to 19% over the same two months.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards