Component
Desulfovibrio desulfuricans CutC choline TMA-lyase
Desulfovibrio desulfuricans CutC choline TMA-lyase. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The characterized anaerobic choline-utilization pathway uses a glycyl-radical choline TMA-lyase to cleave the choline C–N bond and generate TMA.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/23151509.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20246eb796db8ca7b3ff78f530e744bd8f3abe8beb617358b0a1a924166fb2d6", "start_char": 0, "end_char": 1160, "text_sha256": "20246eb796db8ca7b3ff78f530e744bd8f3abe8beb617358b0a1a924166fb2d6"}
- experimental_model
- Anaerobic bacterial genetics, heterologous expression and EPR
- exposure
- Genetic knockout and heterologous expression of choline-utilization genes
- limitations
- A bacterial enzyme pathway, not a direct human-enzyme reaction or evidence that every microbiome produces the same TMA amount.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Desulfovibrio desulfuricans; E. coli expression host
- plain_language
- Gut microbial machinery can divert choline into a different metabolic route.
- primary_references
- [choline-p23151509] Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. (2012). https://pubmed.ncbi.nlm.nih.gov/23151509/ DOI: 10.1073/pnas.1215689109
- tissue_or_cell_type
- Microbial choline-utilization pathway
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 1101–1112
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Anaerobic bacterial genetics, heterologous expression and EPR · source_derived_draft · unverified_draft
### choline-cutc-tma The characterized anaerobic choline-utilization pathway uses a glycyl-radical choline TMA-lyase to cleave the choline C–N bond and generate TMA. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Gut microbial machinery can divert choline into a different metabolic route. organism: Desulfovibrio desulfuricans; E. coli expression host tissue_or_cell_type: Microbial choline-utilization pathway experimental_model: Anaerobic bacterial genetics, heterologous expression and EPR limitations: A bacterial enzyme pathway, not a direct human-enzyme reaction or evidence that every microbiome produces the same TMA amount. exposure: Genetic knockout and heterologous expression of choline-utilization genes evidence_span: {"source_cache": "artifacts/choline-research/23151509.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "20246eb796db8ca7b3ff78f530e744bd8f3abe8beb617358b0a1a924166fb2d6", "start_char": 0, "end_char": 1160, "text_sha256": "20246eb796db8ca7b3ff78f530e744bd8f3abe8beb617358b0a1a924166fb2d6"} [choline-p23151509] Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. (2012). https://pubmed.ncbi.nlm.nih.gov/23151509/ DOI: 10.1073/pnas.1215689109
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.