Component

Canine cystic fibrosis transmembrane conductance regulator / CFTR

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Steviol acutely reduced forskolin-stimulated apical chloride current in canine MDCK epithelia.

    Steviol → Canine cystic fibrosis transmembrane conductance regulator / CFTR source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Canine kidney epithelial Ussing-chamber measurements; concentration-dependent bath exposure.
    limitations
    The source identifies CFTR-associated current; this is not a human dietary chloride-depletion mechanism.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Chloride movement can determine fluid accumulation in a tissue model.
    primary_references
    Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23536832/ · DOI 10.1371/journal.pone.0058871

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 298–304

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Canine kidney epithelial Ussing-chamber measurements; concentration-dependent bath exposure. · source_derived_draft · unverified_draft

    ## stevia-cftr-current Chloride movement can determine fluid accumulation in a tissue model. Steviol acutely reduced forskolin-stimulated apical chloride current in canine MDCK epithelia. Model: Canine kidney epithelial Ussing-chamber measurements; concentration-dependent bath exposure. Limitations: The source identifies CFTR-associated current; this is not a human dietary chloride-depletion mechanism. Evidence access: Primary abstract Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23536832/ · DOI 10.1371/journal.pone.0058871
    Complete structured claim and evidence

  2. Steviol at 100 micromolar for 24 hours reduced CFTR protein expression in MDCK cells; MG-132 abolished the expression effect.

    Steviol → Canine cystic fibrosis transmembrane conductance regulator / CFTR source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Canine MDCK culture with proteasome-inhibitor intervention.
    limitations
    Proteasomal involvement is supported; a specific ubiquitination enzyme or human treatment effect is not established.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    A longer exposure changes protein abundance as well as acute channel activity.
    primary_references
    Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23536832/ · DOI 10.1371/journal.pone.0058871

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 306–312

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Canine MDCK culture with proteasome-inhibitor intervention. · source_derived_draft · unverified_draft

    ## stevia-cftr-degradation A longer exposure changes protein abundance as well as acute channel activity. Steviol at 100 micromolar for 24 hours reduced CFTR protein expression in MDCK cells; MG-132 abolished the expression effect. Model: Canine MDCK culture with proteasome-inhibitor intervention. Limitations: Proteasomal involvement is supported; a specific ubiquitination enzyme or human treatment effect is not established. Evidence access: Primary abstract Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23536832/ · DOI 10.1371/journal.pone.0058871
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Steviol at 100 micromolar reversibly inhibited MDCK cyst formation and growth; doses up to 200 micromolar did not alter measured cell viability, proliferation or apoptosis.

    Steviol → Canine MDCK cyst growth source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Three-dimensional canine kidney cyst culture.
    limitations
    This does not show clinical treatment of human polycystic kidney disease.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Reduced fluid-secretion-associated growth was separable from measured cell killing in this assay.
    primary_references
    Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23536832/ · DOI 10.1371/journal.pone.0058871

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 314–320

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Three-dimensional canine kidney cyst culture. · source_derived_draft · unverified_draft

    ## stevia-cyst-growth Reduced fluid-secretion-associated growth was separable from measured cell killing in this assay. Steviol at 100 micromolar reversibly inhibited MDCK cyst formation and growth; doses up to 200 micromolar did not alter measured cell viability, proliferation or apoptosis. Model: Three-dimensional canine kidney cyst culture. Limitations: This does not show clinical treatment of human polycystic kidney disease. Evidence access: Primary abstract Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23536832/ · DOI 10.1371/journal.pone.0058871
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards