Component
Docosahexaenoic acid / DHA, omega-3 fatty acid
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
DHA co-feeding did not prevent CLA-associated loss of adipose mass or its gene-expression changes.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Same four-week mouse experiment.
- limitations
- Liver and adipose outcomes must remain distinct.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- The same combination did not rescue every tissue.
- primary_references
- The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 230–236
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same four-week mouse experiment. · source_derived_draft · unverified_draft
## cla-dha-adipose The same combination did not rescue every tissue. DHA co-feeding did not prevent CLA-associated loss of adipose mass or its gene-expression changes. Model: Same four-week mouse experiment. Limitations: Liver and adipose outcomes must remain distinct. Evidence access: Primary abstract The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116
Complete structured claim and evidenceAdding 1.5% DHA to 0.5% t10,c12 CLA prevented the CLA-associated increase in liver fat.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Female C57BL/6N mice; four-week feeding study.
- limitations
- High experimental diet proportions; not established human supplement protection.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Another fatty acid changed the liver response.
- primary_references
- The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 222–228
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Female C57BL/6N mice; four-week feeding study. · source_derived_draft · unverified_draft
## cla-dha-liver Another fatty acid changed the liver response. Adding 1.5% DHA to 0.5% t10,c12 CLA prevented the CLA-associated increase in liver fat. Model: Female C57BL/6N mice; four-week feeding study. Limitations: High experimental diet proportions; not established human supplement protection. Evidence access: Primary abstract The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.