{"id":"2ddd60ff-7b0b-5b30-bbbb-b60d929bdf30","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-dha-liver","predicate":"prevents_in_model","statement":"Adding 1.5% DHA to 0.5% t10,c12 CLA prevented the CLA-associated increase in liver fat.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cc386701-d79d-5f62-997a-dd5c24da7363","mechanism_event_label":"Another fatty acid changed the liver response.","subject":{"id":"08b81fb6-0707-5959-856e-ea1f20b1e412","slug":"docosahexaenoic-acid","display_name":"Docosahexaenoic acid / DHA, omega-3 fatty acid","entity_type_key":"small_molecule"},"object":{"id":"379cafac-b5aa-5eac-83fe-ae357f9ede01","slug":"mouse-hepatic-lipid-accumulation","display_name":"Mouse hepatic lipid accumulation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cc386701-d79d-5f62-997a-dd5c24da7363","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-dha-liver-event","event_type":"observed_relationship","label":"Another fatty acid changed the liver response.","description":"Adding 1.5% DHA to 0.5% t10,c12 CLA prevented the CLA-associated increase in liver fat.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"08b81fb6-0707-5959-856e-ea1f20b1e412","slug":"docosahexaenoic-acid","display_name":"Docosahexaenoic acid / DHA, omega-3 fatty acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"379cafac-b5aa-5eac-83fe-ae357f9ede01","slug":"mouse-hepatic-lipid-accumulation","display_name":"Mouse hepatic lipid accumulation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Female C57BL/6N mice; four-week feeding study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High experimental diet proportions; not established human supplement protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Another fatty acid changed the liver response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"79e5549e-b37e-5ea8-ba93-12add9ab5302","evidence_kind":"source_excerpt","locator":"Lines 222-228","start_line":222,"end_line":228,"excerpt":"## cla-dha-liver\nAnother fatty acid changed the liver response.\nAdding 1.5% DHA to 0.5% t10,c12 CLA prevented the CLA-associated increase in liver fat.\nModel: Female C57BL/6N mice; four-week feeding study.\nLimitations: High experimental diet proportions; not established human supplement protection.\nEvidence access: Primary abstract\nThe effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116","model_system":"Female C57BL/6N mice; four-week feeding study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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