{"id":"cfc259d1-cdfa-5d58-9dd8-8cf176016bf4","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-dha-adipose","predicate":"does_not_prevent","statement":"DHA co-feeding did not prevent CLA-associated loss of adipose mass or its gene-expression changes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5c948c35-79f2-505f-a397-9f3542ae019d","mechanism_event_label":"The same combination did not rescue every tissue.","subject":{"id":"08b81fb6-0707-5959-856e-ea1f20b1e412","slug":"docosahexaenoic-acid","display_name":"Docosahexaenoic acid / DHA, omega-3 fatty acid","entity_type_key":"small_molecule"},"object":{"id":"25f7e9fd-57c1-592c-ad70-3ee6f3f7db42","slug":"mouse-adipose-mass","display_name":"Mouse adipose tissue mass","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5c948c35-79f2-505f-a397-9f3542ae019d","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-dha-adipose-event","event_type":"observed_relationship","label":"The same combination did not rescue every tissue.","description":"DHA co-feeding did not prevent CLA-associated loss of adipose mass or its gene-expression changes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"08b81fb6-0707-5959-856e-ea1f20b1e412","slug":"docosahexaenoic-acid","display_name":"Docosahexaenoic acid / DHA, omega-3 fatty acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"25f7e9fd-57c1-592c-ad70-3ee6f3f7db42","slug":"mouse-adipose-mass","display_name":"Mouse adipose tissue mass","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same four-week mouse experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Liver and adipose outcomes must remain distinct.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The same combination did not rescue every tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dc8675c6-a7c8-51ab-92c6-e0e3bcf331f3","evidence_kind":"source_excerpt","locator":"Lines 230-236","start_line":230,"end_line":236,"excerpt":"## cla-dha-adipose\nThe same combination did not rescue every tissue.\nDHA co-feeding did not prevent CLA-associated loss of adipose mass or its gene-expression changes.\nModel: Same four-week mouse experiment.\nLimitations: Liver and adipose outcomes must remain distinct.\nEvidence access: Primary abstract\nThe effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23170930/ · DOI 10.1089/met.2012.0116","model_system":"Same four-week mouse experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}