Component

Hydroxylated DIM metabolites, mixed analytical pool

Hydroxylated DIM metabolites, mixed analytical pool. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Glucuronide conjugates of hydroxylated DIM products were detected in human samples.

    Hydroxylated DIM metabolites, mixed analytical pool → DIM-derived glucuronide conjugates, mixed analytical pool source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"}
    experimental_model
    Human serial plasma/urine mass spectrometry and reporter assays
    exposure
    Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule
    limitations
    Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response.
    nutrient_topic
    Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
    organism
    Seven adults; mouse Hepa1 reporter cells
    plain_language
    A second processing step attaches a conjugating group; parent DIM alone misses this pool.
    primary_references
    [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    tissue_or_cell_type
    DIM metabolism and metabolite signaling

    Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 220–231

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human serial plasma/urine mass spectrometry and reporter assays · source_derived_draft · unverified_draft

    ### dim-dim-glucuronidation Glucuronide conjugates of hydroxylated DIM products were detected in human samples. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: A second processing step attaches a conjugating group; parent DIM alone misses this pool. organism: Seven adults; mouse Hepa1 reporter cells tissue_or_cell_type: DIM metabolism and metabolite signaling experimental_model: Human serial plasma/urine mass spectrometry and reporter assays limitations: Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response. exposure: Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule evidence_span: {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"} [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    Complete structured claim and evidence

  2. Sulfate conjugates of hydroxylated DIM products were detected in human samples.

    Hydroxylated DIM metabolites, mixed analytical pool → DIM-derived sulfate conjugates, mixed analytical pool source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"}
    experimental_model
    Human serial plasma/urine mass spectrometry and reporter assays
    exposure
    Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule
    limitations
    Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response.
    nutrient_topic
    Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
    organism
    Seven adults; mouse Hepa1 reporter cells
    plain_language
    Sulfur-containing conjugation is another handling route; its presence does not demonstrate sulfate depletion.
    primary_references
    [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    tissue_or_cell_type
    DIM metabolism and metabolite signaling

    Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 233–244

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human serial plasma/urine mass spectrometry and reporter assays · source_derived_draft · unverified_draft

    ### dim-dim-sulfation Sulfate conjugates of hydroxylated DIM products were detected in human samples. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Sulfur-containing conjugation is another handling route; its presence does not demonstrate sulfate depletion. organism: Seven adults; mouse Hepa1 reporter cells tissue_or_cell_type: DIM metabolism and metabolite signaling experimental_model: Human serial plasma/urine mass spectrometry and reporter assays limitations: Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response. exposure: Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule evidence_span: {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"} [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    Complete structured claim and evidence

What acts on it

  1. Two monohydroxylated and one dihydroxylated DIM products appeared in human plasma and urine.

    3,3'-Diindolylmethane / DIM → Hydroxylated DIM metabolites, mixed analytical pool source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"}
    experimental_model
    Human serial plasma/urine mass spectrometry and reporter assays
    exposure
    Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule
    limitations
    Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response.
    nutrient_topic
    Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
    organism
    Seven adults; mouse Hepa1 reporter cells
    plain_language
    The body changes DIM into additional molecules that need their own records.
    primary_references
    [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    tissue_or_cell_type
    DIM metabolism and metabolite signaling

    Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 207–218

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human serial plasma/urine mass spectrometry and reporter assays · source_derived_draft · unverified_draft

    ### dim-dim-hydroxylation Two monohydroxylated and one dihydroxylated DIM products appeared in human plasma and urine. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: The body changes DIM into additional molecules that need their own records. organism: Seven adults; mouse Hepa1 reporter cells tissue_or_cell_type: DIM metabolism and metabolite signaling experimental_model: Human serial plasma/urine mass spectrometry and reporter assays limitations: Small mixed-sex sample. Product label mass and measured DIM content differ. Some metabolite structures were tentative; reporter activity was not a clinical response. exposure: Two BR-DIM 150 capsules nightly for one week; measured 45.3 mg DIM per capsule evidence_span: {"source_cache": "artifacts/dim-research/34035125.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff", "start_char": 0, "end_char": 2514, "text_sha256": "0df37954db1da2ae488edb763e1397977b65d206cdd52269a5a882b62e8748ff"} [dim-p34035125] 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. (2021). https://pubmed.ncbi.nlm.nih.gov/34035125/ DOI: 10.1124/dmd.120.000346
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards