Component

DHVAR4 antimicrobial peptide

Synthetic histatin-derived antimicrobial peptide; not the entire salivary histatin family or an established oral therapy.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Tartrazine formed assemblies with the synthetic antimicrobial peptide DHVAR4.

    Tartrazine → DHVAR4 antimicrobial peptide source_derived_draftungraded
    Experimental context and source evidence
    dose
    DHVAR4 plus tartrazine; concentrations and ratios not specified in accessed abstract
    duration
    Assay intervals not specified in accessed abstract
    evidence_access
    Primary PubMed abstract; unrecovered method details explicitly retained.
    evidence_scope
    literature_reviewed; source-specific experimental curation
    experimental_model
    Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures
    limitations
    No clinical antimicrobial efficacy or effect on all natural histatins is established. Species-specific bactericidal thresholds and mammalian exposure require the full protocol.
    nutrient_topic
    Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
    organism
    Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures
    plain_language
    Tartrazine formed assemblies with the synthetic antimicrobial peptide DHVAR4.
    primary_references
    Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity. (2020). https://pubmed.ncbi.nlm.nih.gov/32115014/ DOI: 10.1017/S0033583520000013
    route
    In vitro mixing and membrane/bacterial assays
    tissue
    Peptide-dye association and membrane activity

    Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 402–411

    Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures · source_derived_draft · unverified_draft

    ## tartrazine-peptide-association Tartrazine formed assemblies with the synthetic antimicrobial peptide DHVAR4. Model/species: Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures Tissue: Peptide-dye association and membrane activity Exposure: DHVAR4 plus tartrazine; concentrations and ratios not specified in accessed abstract Route: In vitro mixing and membrane/bacterial assays Duration: Assay intervals not specified in accessed abstract Limits: No clinical antimicrobial efficacy or effect on all natural histatins is established. Species-specific bactericidal thresholds and mammalian exposure require the full protocol. Primary reference: Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity. (2020). https://pubmed.ncbi.nlm.nih.gov/32115014/ DOI: 10.1017/S0033583520000013 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Tartrazine increased DHVAR4 antibacterial activity in the tested cultures.

    Tartrazine → DHVAR4 antibacterial activity against tested Gram-positive and Gram-negative bacteria source_derived_draftungraded
    Experimental context and source evidence
    dose
    DHVAR4 plus tartrazine; concentrations and ratios not specified in accessed abstract
    duration
    Assay intervals not specified in accessed abstract
    evidence_access
    Primary PubMed abstract; unrecovered method details explicitly retained.
    evidence_scope
    literature_reviewed; source-specific experimental curation
    experimental_model
    Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures
    limitations
    No clinical antimicrobial efficacy or effect on all natural histatins is established. Species-specific bactericidal thresholds and mammalian exposure require the full protocol.
    nutrient_topic
    Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
    organism
    Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures
    plain_language
    Tartrazine increased DHVAR4 antibacterial activity in the tested cultures.
    primary_references
    Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity. (2020). https://pubmed.ncbi.nlm.nih.gov/32115014/ DOI: 10.1017/S0033583520000013
    route
    In vitro mixing and membrane/bacterial assays
    tissue
    Peptide-dye association and membrane activity

    Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 424–433

    Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures · source_derived_draft · unverified_draft

    ## tartrazine-peptide-antibacterial Tartrazine increased DHVAR4 antibacterial activity in the tested cultures. Model/species: Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures Tissue: Peptide-dye association and membrane activity Exposure: DHVAR4 plus tartrazine; concentrations and ratios not specified in accessed abstract Route: In vitro mixing and membrane/bacterial assays Duration: Assay intervals not specified in accessed abstract Limits: No clinical antimicrobial efficacy or effect on all natural histatins is established. Species-specific bactericidal thresholds and mammalian exposure require the full protocol. Primary reference: Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity. (2020). https://pubmed.ncbi.nlm.nih.gov/32115014/ DOI: 10.1017/S0033583520000013 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
    Complete structured claim and evidence

  2. Tartrazine favored the membrane-associated helical conformation of DHVAR4.

    Tartrazine → Membrane-associated helical conformation of DHVAR4 source_derived_draftungraded
    Experimental context and source evidence
    dose
    DHVAR4 plus tartrazine; concentrations and ratios not specified in accessed abstract
    duration
    Assay intervals not specified in accessed abstract
    evidence_access
    Primary PubMed abstract; unrecovered method details explicitly retained.
    evidence_scope
    literature_reviewed; source-specific experimental curation
    experimental_model
    Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures
    limitations
    No clinical antimicrobial efficacy or effect on all natural histatins is established. Species-specific bactericidal thresholds and mammalian exposure require the full protocol.
    nutrient_topic
    Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
    organism
    Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures
    plain_language
    Tartrazine favored the membrane-associated helical conformation of DHVAR4.
    primary_references
    Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity. (2020). https://pubmed.ncbi.nlm.nih.gov/32115014/ DOI: 10.1017/S0033583520000013
    route
    In vitro mixing and membrane/bacterial assays
    tissue
    Peptide-dye association and membrane activity

    Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 413–422

    Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures · source_derived_draft · unverified_draft

    ## tartrazine-peptide-helix Tartrazine favored the membrane-associated helical conformation of DHVAR4. Model/species: Synthetic histatin-derived DHVAR4 peptide, model lipid bilayers and tested bacterial cultures Tissue: Peptide-dye association and membrane activity Exposure: DHVAR4 plus tartrazine; concentrations and ratios not specified in accessed abstract Route: In vitro mixing and membrane/bacterial assays Duration: Assay intervals not specified in accessed abstract Limits: No clinical antimicrobial efficacy or effect on all natural histatins is established. Species-specific bactericidal thresholds and mammalian exposure require the full protocol. Primary reference: Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity. (2020). https://pubmed.ncbi.nlm.nih.gov/32115014/ DOI: 10.1017/S0033583520000013 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards