Component

3-Deoxy-D-arabino-heptulosonate 7-phosphate / DAHP

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. AroB converts DAHP into 3-dehydroquinate.

    3-Deoxy-D-arabino-heptulosonate 7-phosphate / DAHP → 3-Dehydroquinate / DHQ source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
    experimental_model
    Escherichia coli biochemical pathway; source-specific enzyme evidence recorded in the passage.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    AroB converts DAHP into 3-dehydroquinate.
    primary_references
    Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose-xylose co-substrate. | 2020 | DOI 10.1038/s41467-019-14024-1 | PMID 31937786 | https://pubmed.ncbi.nlm.nih.gov/31937786/ | https://doi.org/10.1038/s41467-019-14024-1 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6959354/
    source_locator
    Reviewed reference lines 11-11; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 11–11

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Escherichia coli biochemical pathway; source-specific enzyme evidence recorded in the passage. · source_derived_draft · unverified_draft

    **The two steps before shikimate.** E. coli AroB converts DAHP to 3-dehydroquinate (DHQ); AroD dehydrates DHQ to 3-dehydroshikimate (DHS). DHS and shikimate are different metabolites. Separating these intermediates matters when metabolomics shows them accumulating during downstream inhibition. [Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose-xylose co-substrate.](https://pubmed.ncbi.nlm.nih.gov/31937786/)
    Complete structured claim and evidence

What acts on it

  1. DAHP synthase combines PEP and erythrose-4-phosphate into DAHP.

    Phosphoenolpyruvate / PEP → 3-Deoxy-D-arabino-heptulosonate 7-phosphate / DAHP source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction. Primary correction read: duplicated Fig. 7 and incorrect panel reference corrected; not a retraction.
    experimental_model
    Escherichia coli biochemical pathway; source-specific enzyme evidence recorded in the passage.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    DAHP synthase combines PEP and erythrose-4-phosphate into DAHP.
    primary_references
    Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose-xylose co-substrate. | 2020 | DOI 10.1038/s41467-019-14024-1 | PMID 31937786 | https://pubmed.ncbi.nlm.nih.gov/31937786/ | https://doi.org/10.1038/s41467-019-14024-1 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6959354/
    primary_references
    Publisher correction to metabolic engineering of Escherichia coli for shikimate pathway derivative production | 2020 | DOI 10.1038/s41467-020-14710-5 | https://www.nature.com/articles/s41467-020-14710-5
    source_locator
    Reviewed reference lines 9-9; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 9–9

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Escherichia coli biochemical pathway; source-specific enzyme evidence recorded in the passage. · source_derived_draft · unverified_draft

    **Carbon entry: DAHP formation.** The E. coli pathway map joins phosphoenolpyruvate (PEP) and erythrose-4-phosphate (E4P) through DAHP synthase to form 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP), releasing phosphate. These inputs connect central carbon metabolism to aromatic biosynthesis. The cited engineering study provides pathway and flux-redistribution context; its diagram is not a new kinetic assay for every reaction. Its 2020 publisher correction replaces a duplicated Figure 7 and corrects its legend; the current corrected article is the reference. [Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose-xylose co-substrate.](https://pubmed.ncbi.nlm.nih.gov/31937786/) [Publisher correction to metabolic engineering of Escherichia coli for shikimate pathway derivative production](https://www.nature.com/articles/s41467-020-14710-5)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.