Component

Corpus cavernosum smooth muscle relaxation

Relaxation of isolated erectile tissue on activation of a signalling cascade.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Corpora cavernosa from mice lacking cGMP-dependent kinase I failed to relax when the nitric oxide and cGMP signalling cascade was activated.

    cGMP-dependent protein kinase I → Corpus cavernosum smooth muscle relaxation source_derived_draftungraded
    Experimental context and source evidence
    duration
    Acute
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    cGMP-dependent kinase I null mice compared with normal mice
    exposure
    Activation of the NO/cGMP cascade
    limitations
    A whole-body knockout rather than tissue-specific deletion; the mice also had a very low ability to reproduce, while their sperm were normal and could fertilise eggs.
    organism
    cGMP-dependent kinase I null mice compared with normal mice
    plain_language
    Corpora cavernosa from mice lacking cGMP-dependent kinase I failed to relax when the nitric oxide and cGMP signalling cascade was activated.
    primary_references
    Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. (2000). https://pubmed.ncbi.nlm.nih.gov/10688876/ DOI: 10.1073/pnas.030419997
    route
    Isolated tissue
    tissue
    Corpus cavernosum smooth muscle relaxation

    Tadalafil: PDE5 occupancy, the cGMP route and three measured endpoints (2026-09-22) · lines 56–65

    Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata. Two references carry an unresolvable erratum and are recorded as corrected. Study-specific doses, effect sizes and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft

    ## cgmp-dependent-kinase-i-carries-the-relaxation Corpora cavernosa from mice lacking cGMP-dependent kinase I failed to relax when the nitric oxide and cGMP signalling cascade was activated. Model/species: cGMP-dependent kinase I null mice compared with normal mice Tissue/system: Corpus cavernosum smooth muscle relaxation Exposure: Activation of the NO/cGMP cascade Route: Isolated tissue Duration: Acute Limits: A whole-body knockout rather than tissue-specific deletion; the mice also had a very low ability to reproduce, while their sperm were normal and could fertilise eggs. Primary reference: Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. (2000). https://pubmed.ncbi.nlm.nih.gov/10688876/ DOI: 10.1073/pnas.030419997 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

  2. Raising cyclic AMP with forskolin produced similar relaxation in normal and cGMP-dependent kinase I null corpus cavernosum.

    cGMP-dependent protein kinase I → Corpus cavernosum smooth muscle relaxation source_derived_draftungraded
    Experimental context and source evidence
    duration
    Acute
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    cGMP-dependent kinase I null mice compared with normal mice
    exposure
    Forskolin
    limitations
    Shows an intact parallel cAMP route in isolated tissue; the authors conclude cAMP signalling cannot compensate for the absent cGMP cascade in vivo, which is an inference from the reproductive phenotype rather than a separate measurement.
    organism
    cGMP-dependent kinase I null mice compared with normal mice
    plain_language
    Raising cyclic AMP with forskolin produced similar relaxation in normal and cGMP-dependent kinase I null corpus cavernosum.
    primary_references
    Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. (2000). https://pubmed.ncbi.nlm.nih.gov/10688876/ DOI: 10.1073/pnas.030419997
    route
    Isolated tissue
    tissue
    Corpus cavernosum smooth muscle relaxation

    Tadalafil: PDE5 occupancy, the cGMP route and three measured endpoints (2026-09-22) · lines 67–76

    Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata. Two references carry an unresolvable erratum and are recorded as corrected. Study-specific doses, effect sizes and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft

    ## cyclic-amp-does-not-substitute-for-the-cgmp-route Raising cyclic AMP with forskolin produced similar relaxation in normal and cGMP-dependent kinase I null corpus cavernosum. Model/species: cGMP-dependent kinase I null mice compared with normal mice Tissue/system: Corpus cavernosum smooth muscle relaxation Exposure: Forskolin Route: Isolated tissue Duration: Acute Limits: Shows an intact parallel cAMP route in isolated tissue; the authors conclude cAMP signalling cannot compensate for the absent cGMP cascade in vivo, which is an inference from the reproductive phenotype rather than a separate measurement. Primary reference: Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. (2000). https://pubmed.ncbi.nlm.nih.gov/10688876/ DOI: 10.1073/pnas.030419997 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.

    Phosphodiesterase 5 family → Cyclic guanosine monophosphate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    Human corpus cavernosum tissue, as stated in a structural report
    exposure
    Not applicable
    limitations
    Stated as established background in this structural paper rather than measured in it; twelve PDE gene families exist and others are present in the same tissue.
    organism
    Human corpus cavernosum tissue, as stated in a structural report
    plain_language
    cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.
    primary_references
    Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (2003). https://pubmed.ncbi.nlm.nih.gov/12955149/ DOI: 10.1038/nature01914
    route
    Not applicable
    tissue
    Cyclic nucleotide degradation

    Tadalafil: PDE5 occupancy, the cGMP route and three measured endpoints (2026-09-22) · lines 46–54

    Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata. Two references carry an unresolvable erratum and are recorded as corrected. Study-specific doses, effect sizes and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft

    ## pde5-hydrolyses-cgmp-in-corpus-cavernosum cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue. Model/species: Human corpus cavernosum tissue, as stated in a structural report Tissue/system: Cyclic nucleotide degradation Exposure: Not applicable Route: Not applicable Limits: Stated as established background in this structural paper rather than measured in it; twelve PDE gene families exist and others are present in the same tissue. Primary reference: Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (2003). https://pubmed.ncbi.nlm.nih.gov/12955149/ DOI: 10.1038/nature01914 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards