{"id":"0580f383-42da-5b9f-926a-5c2e8ac49606","stable_key":"8ccb5461-efe2-5d95-9869-950d7cd50575:pde5-hydrolyses-cgmp-in-corpus-cavernosum","predicate":"hydrolyses","statement":"cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d31ae42d-d968-5863-8f9e-8372252cee0f","mechanism_event_label":"cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.","subject":{"id":"0be8b435-6b8a-592c-bd4c-c0efd9481a97","slug":"pde5-family","display_name":"Phosphodiesterase 5 family","entity_type_key":"protein_family"},"object":{"id":"6d2f509b-3a5b-5a38-b3e7-b148581edec9","slug":"cgmp","display_name":"Cyclic guanosine monophosphate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d31ae42d-d968-5863-8f9e-8372252cee0f","stable_key":"8ccb5461-efe2-5d95-9869-950d7cd50575:pde5-hydrolyses-cgmp-in-corpus-cavernosum-event","event_type":"observed_relationship","label":"cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.","description":"cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0be8b435-6b8a-592c-bd4c-c0efd9481a97","slug":"pde5-family","display_name":"Phosphodiesterase 5 family","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6d2f509b-3a5b-5a38-b3e7-b148581edec9","slug":"cgmp","display_name":"Cyclic guanosine monophosphate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a0f443db-03a6-5fc6-bdaf-f83d943458de","slug":"corpus-cavernosum-relaxation","display_name":"Corpus cavernosum smooth muscle relaxation","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human corpus cavernosum tissue, as stated in a structural report","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Not applicable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Stated as established background in this structural paper rather than measured in it; twelve PDE gene families exist and others are present in the same tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human corpus cavernosum tissue, as stated in a structural report","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (2003). https://pubmed.ncbi.nlm.nih.gov/12955149/ DOI: 10.1038/nature01914","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Not applicable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Cyclic nucleotide degradation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"60ced021-887a-523c-850d-aef0aaf5c955","evidence_kind":"source_excerpt","locator":"Lines 46-54","start_line":46,"end_line":54,"excerpt":"## pde5-hydrolyses-cgmp-in-corpus-cavernosum\ncGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue.\nModel/species: Human corpus cavernosum tissue, as stated in a structural report\nTissue/system: Cyclic nucleotide degradation\nExposure: Not applicable\nRoute: Not applicable\nLimits: Stated as established background in this structural paper rather than measured in it; twelve PDE gene families exist and others are present in the same tissue.\nPrimary reference: Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (2003). https://pubmed.ncbi.nlm.nih.gov/12955149/ DOI: 10.1038/nature01914\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"cca24ae7-e036-525c-a440-4cc2e38ccb4d","stable_key":"import-8ccb5461-efe2-5d95-9869-950d7cd50575","title":"Tadalafil: PDE5 occupancy, the cGMP route and three measured endpoints (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata. Two references carry an unresolvable erratum and are recorded as corrected. Study-specific doses, effect sizes and limitations retained. Not publisher full text.","file_path":"","sha256":"3df8ec8f7114f983e8cae9fbc54912d3ac5b5f962454afea9dd8d4438c94cded","revision_id":"510acdea-65ae-57a6-b743-68e031ff1f05","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}