Component
Coenzyme Q precursor O-methylation
Coenzyme Q precursor O-methylation. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Human COQ3 showed O-methyltransferase activity with early and final CoQ-intermediate analogues.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/10777520.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd", "start_char": 0, "end_char": 1345, "text_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd"}
- experimental_model
- Human gene expression in yeast and methyltransferase assays
- exposure
- Farnesylated substrate analogues
- limitations
- Engineered complementation and analogue assays; not a human methyl-donor supplementation trial.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- Human COQ3 in yeast and cell-free assays
- plain_language
- The same enzyme performs methylation at two stages of CoQ assembly.
- primary_references
- [coq10-p10777520] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10777520/ DOI: 10.1074/jbc.275.17.12381
- tissue_or_cell_type
- Early and final CoQ intermediates
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 242–253
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human gene expression in yeast and methyltransferase assays · source_derived_draft · unverified_draft
### coq10-coq3-methylation Human COQ3 showed O-methyltransferase activity with early and final CoQ-intermediate analogues. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same enzyme performs methylation at two stages of CoQ assembly. organism: Human COQ3 in yeast and cell-free assays tissue_or_cell_type: Early and final CoQ intermediates experimental_model: Human gene expression in yeast and methyltransferase assays limitations: Engineered complementation and analogue assays; not a human methyl-donor supplementation trial. exposure: Farnesylated substrate analogues evidence_span: {"source_cache": "artifacts/coq10-research/10777520.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd", "start_char": 0, "end_char": 1345, "text_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd"} [coq10-p10777520] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10777520/ DOI: 10.1074/jbc.275.17.12381
Complete structured claim and evidence
Where it participates (unsigned role)
COQ3 methylated the tested precursor in the presence of SAM.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coq10-research/38425362.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d25af4ecd7340649536b8fea3b8a0a308a1611bbf8c57f6a79b362f443f1cba", "start_char": 13814, "end_char": 15577, "text_sha256": "c43de1ac5dc6711fad8e37af3a52a8cd9784ed7eeaf77bd2981afe72abaf307f"}
- experimental_model
- Purified reconstructed COQ metabolon with short-chain substrates
- exposure
- Enzyme combinations, methyl donors, reductants and metal additions
- limitations
- Ancestral proteins and CoQ1 analogues; no clinical cofactor dose or proof of nutritional rate limitation. Reaction order need not be universal across species.
- nutrient_topic
- Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
- organism
- Reconstructed ancestral tetrapod proteins
- plain_language
- CoQ synthesis shares the methyl-donor pool used by other pathways.
- primary_references
- [coq10-p38425362] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis. (2024). https://pubmed.ncbi.nlm.nih.gov/38425362/ DOI: 10.1038/s41929-023-01087-z
- tissue_or_cell_type
- Stepwise CoQ head-group assembly
Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 645–656
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified reconstructed COQ metabolon with short-chain substrates · source_derived_draft · unverified_draft
### coq10-coq3-sam COQ3 methylated the tested precursor in the presence of SAM. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: CoQ synthesis shares the methyl-donor pool used by other pathways. organism: Reconstructed ancestral tetrapod proteins tissue_or_cell_type: Stepwise CoQ head-group assembly experimental_model: Purified reconstructed COQ metabolon with short-chain substrates limitations: Ancestral proteins and CoQ1 analogues; no clinical cofactor dose or proof of nutritional rate limitation. Reaction order need not be universal across species. exposure: Enzyme combinations, methyl donors, reductants and metal additions evidence_span: {"source_cache": "artifacts/coq10-research/38425362.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d25af4ecd7340649536b8fea3b8a0a308a1611bbf8c57f6a79b362f443f1cba", "start_char": 13814, "end_char": 15577, "text_sha256": "c43de1ac5dc6711fad8e37af3a52a8cd9784ed7eeaf77bd2981afe72abaf307f"} [coq10-p38425362] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis. (2024). https://pubmed.ncbi.nlm.nih.gov/38425362/ DOI: 10.1038/s41929-023-01087-z
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.