Component

Human CoQ O-methyltransferase / COQ3

Human CoQ O-methyltransferase / COQ3. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Human COQ3 showed O-methyltransferase activity with early and final CoQ-intermediate analogues.

    Human CoQ O-methyltransferase / COQ3 → Coenzyme Q precursor O-methylation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/10777520.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd", "start_char": 0, "end_char": 1345, "text_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd"}
    experimental_model
    Human gene expression in yeast and methyltransferase assays
    exposure
    Farnesylated substrate analogues
    limitations
    Engineered complementation and analogue assays; not a human methyl-donor supplementation trial.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Human COQ3 in yeast and cell-free assays
    plain_language
    The same enzyme performs methylation at two stages of CoQ assembly.
    primary_references
    [coq10-p10777520] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10777520/ DOI: 10.1074/jbc.275.17.12381
    tissue_or_cell_type
    Early and final CoQ intermediates

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 242–253

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human gene expression in yeast and methyltransferase assays · source_derived_draft · unverified_draft

    ### coq10-coq3-methylation Human COQ3 showed O-methyltransferase activity with early and final CoQ-intermediate analogues. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same enzyme performs methylation at two stages of CoQ assembly. organism: Human COQ3 in yeast and cell-free assays tissue_or_cell_type: Early and final CoQ intermediates experimental_model: Human gene expression in yeast and methyltransferase assays limitations: Engineered complementation and analogue assays; not a human methyl-donor supplementation trial. exposure: Farnesylated substrate analogues evidence_span: {"source_cache": "artifacts/coq10-research/10777520.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd", "start_char": 0, "end_char": 1345, "text_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd"} [coq10-p10777520] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10777520/ DOI: 10.1074/jbc.275.17.12381
    Complete structured claim and evidence

  2. Human COQ3 expression rescued respiratory growth and partially restored CoQ synthesis in coq3-null yeast.

    Human CoQ O-methyltransferase / COQ3 → Coenzyme Q biosynthesis source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/coq10-research/10777520.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd", "start_char": 0, "end_char": 1345, "text_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd"}
    experimental_model
    Human gene expression in yeast and methyltransferase assays
    exposure
    Farnesylated substrate analogues
    limitations
    Engineered complementation and analogue assays; not a human methyl-donor supplementation trial.
    nutrient_topic
    Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. · Coenzyme Q10 / CoQ10 redox system
    organism
    Human COQ3 in yeast and cell-free assays
    plain_language
    The human enzyme could replace part of the missing yeast machinery.
    primary_references
    [coq10-p10777520] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10777520/ DOI: 10.1074/jbc.275.17.12381
    tissue_or_cell_type
    Early and final CoQ intermediates

    Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17) · lines 255–266

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human gene expression in yeast and methyltransferase assays · source_derived_draft · unverified_draft

    ### coq10-coq3-rescue Human COQ3 expression rescued respiratory growth and partially restored CoQ synthesis in coq3-null yeast. Condition category: normal nutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The human enzyme could replace part of the missing yeast machinery. organism: Human COQ3 in yeast and cell-free assays tissue_or_cell_type: Early and final CoQ intermediates experimental_model: Human gene expression in yeast and methyltransferase assays limitations: Engineered complementation and analogue assays; not a human methyl-donor supplementation trial. exposure: Farnesylated substrate analogues evidence_span: {"source_cache": "artifacts/coq10-research/10777520.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd", "start_char": 0, "end_char": 1345, "text_sha256": "0acc430af6b08f94dcbd0165e149ff76f9ba6fbfc47fcc934a0476182b4534bd"} [coq10-p10777520] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. (2000). https://pubmed.ncbi.nlm.nih.gov/10777520/ DOI: 10.1074/jbc.275.17.12381
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards