Component
Colonic BK channel abundance
Independent biological entity. Read linked claims for experimental scope and context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Marked BK overexpression accompanied colonic potassium-secretory diarrhea and hypokalemia in the reported patient.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- Single case; symptoms resolved after colectomy.
- limitations
- The proposed shock/ischemia-to-BK chain remains a hypothesis.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Homo sapiens
- plain_language
- Severe potassium loss can occur through the gut even in kidney failure.
- primary_references
- [k-van-dinter2008] Over-expression of colonic K+ channels associated with severe potassium secretory diarrhoea after haemorrhagic shock (2008). https://pubmed.ncbi.nlm.nih.gov/18653901/ DOI: 10.1093/ndt/gfn411
- tissue_or_cell_type
- Human colon
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1498–1507
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single case; symptoms resolved after colectomy. · source_derived_draft · unverified_draft
### k-secretory-diarrhea-bk-case Marked BK overexpression accompanied colonic potassium-secretory diarrhea and hypokalemia in the reported patient. Condition category: nutrient_deficiency nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Severe potassium loss can occur through the gut even in kidney failure. organism: Homo sapiens tissue_or_cell_type: Human colon experimental_model: Single case; symptoms resolved after colectomy. limitations: The proposed shock/ischemia-to-BK chain remains a hypothesis. [k-van-dinter2008] Over-expression of colonic K+ channels associated with severe potassium secretory diarrhoea after haemorrhagic shock (2008). https://pubmed.ncbi.nlm.nih.gov/18653901/ DOI: 10.1093/ndt/gfn411
Complete structured claim and evidence
Where it participates (unsigned role)
Patients with end-stage renal disease showed higher colonic BK expression and approximately threefold higher rectal potassium secretion than controls.
Experimental context and source evidence
- cross_nutrient
- Kidney failure -> extra-renal potassium handling.
- experimental_model
- Small human biopsy and rectal-dialysis groups.
- limitations
- Expression plus association does not identify every flux pathway; no diet intervention.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Homo sapiens
- plain_language
- The colon can increase its potassium-disposal role when kidney function is severely reduced.
- primary_references
- [k-sandle2005] Enhanced large intestinal potassium permeability in end-stage renal disease (2005). https://pubmed.ncbi.nlm.nih.gov/15772943/ DOI: 10.1002/path.1750
- tissue_or_cell_type
- Human distal colon and rectum
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1475–1485
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Small human biopsy and rectal-dialysis groups. · source_derived_draft · unverified_draft
### k-esrd-colonic-bk-upregulation Patients with end-stage renal disease showed higher colonic BK expression and approximately threefold higher rectal potassium secretion than controls. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The colon can increase its potassium-disposal role when kidney function is severely reduced. organism: Homo sapiens tissue_or_cell_type: Human distal colon and rectum experimental_model: Small human biopsy and rectal-dialysis groups. limitations: Expression plus association does not identify every flux pathway; no diet intervention. cross_nutrient: Kidney failure -> extra-renal potassium handling. [k-sandle2005] Enhanced large intestinal potassium permeability in end-stage renal disease (2005). https://pubmed.ncbi.nlm.nih.gov/15772943/ DOI: 10.1002/path.1750
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.