{"id":"47bd2aa1-7c18-58a3-8c63-cda99a42feb8","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-esrd-colonic-bk-upregulation","predicate":"increased_abundance_associates_with","statement":"Patients with end-stage renal disease showed higher colonic BK expression and approximately threefold higher rectal potassium secretion than controls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3061f6c6-78c9-5e91-92fe-49966efe0089","mechanism_event_label":"The colon can increase its potassium-disposal role when kidney function is severely reduced.","subject":{"id":"3774e390-948f-57ec-b2ee-052930a9ec6c","slug":"kcnma1","display_name":"Large-conductance calcium-activated potassium channel alpha subunit","entity_type_key":"protein"},"object":{"id":"7ce59808-94a1-5919-a371-6640ecc42672","slug":"colonic-potassium-secretion","display_name":"Colonic potassium secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3061f6c6-78c9-5e91-92fe-49966efe0089","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-esrd-colonic-bk-upregulation-event","event_type":"observed_intervention","label":"The colon can increase its potassium-disposal role when kidney function is severely reduced.","description":"Patients with end-stage renal disease showed higher colonic BK expression and approximately threefold higher rectal potassium secretion than controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"secreted_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"095d97bd-3ce6-5f5c-b685-a678dbced325","slug":"colonic-bk-abundance","display_name":"Colonic BK channel abundance","entity_type_key":"cellular_process"},"role":"measured_expression","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3774e390-948f-57ec-b2ee-052930a9ec6c","slug":"kcnma1","display_name":"Large-conductance calcium-activated potassium channel alpha subunit","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7ce59808-94a1-5919-a371-6640ecc42672","slug":"colonic-potassium-secretion","display_name":"Colonic potassium secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Kidney failure -> extra-renal potassium handling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small human biopsy and rectal-dialysis groups.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression plus association does not identify every flux pathway; no diet intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The colon can increase its potassium-disposal role when kidney function is severely reduced.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-sandle2005] Enhanced large intestinal potassium permeability in end-stage renal disease (2005). https://pubmed.ncbi.nlm.nih.gov/15772943/ DOI: 10.1002/path.1750","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human distal colon and rectum","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7ca9295f-eeb6-51e6-8116-abf5cd05a325","evidence_kind":"source_excerpt","locator":"Lines 1475-1485","start_line":1475,"end_line":1485,"excerpt":"### k-esrd-colonic-bk-upregulation\nPatients with end-stage renal disease showed higher colonic BK expression and approximately threefold higher rectal potassium secretion than controls.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The colon can increase its potassium-disposal role when kidney function is severely reduced.\norganism: Homo sapiens\ntissue_or_cell_type: Human distal colon and rectum\nexperimental_model: Small human biopsy and rectal-dialysis groups.\nlimitations: Expression plus association does not identify every flux pathway; no diet intervention.\ncross_nutrient: Kidney failure -> extra-renal potassium handling.\n[k-sandle2005] Enhanced large intestinal potassium permeability in end-stage renal disease (2005). https://pubmed.ncbi.nlm.nih.gov/15772943/ DOI: 10.1002/path.1750","model_system":"Small human biopsy and rectal-dialysis groups.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-sandle2005] Enhanced large intestinal potassium permeability in end-stage renal disease (2005). https://pubmed.ncbi.nlm.nih.gov/15772943/ DOI: 10.1002/path.1750","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}