{"id":"0253768f-912c-59ba-a5f7-518a9540d7da","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-secretory-diarrhea-bk-case","predicate":"is_associated_with","statement":"Marked BK overexpression accompanied colonic potassium-secretory diarrhea and hypokalemia in the reported patient.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c2726087-c6bb-5976-932b-e9555387ed94","mechanism_event_label":"Severe potassium loss can occur through the gut even in kidney failure.","subject":{"id":"095d97bd-3ce6-5f5c-b685-a678dbced325","slug":"colonic-bk-abundance","display_name":"Colonic BK channel abundance","entity_type_key":"cellular_process"},"object":{"id":"7ce59808-94a1-5919-a371-6640ecc42672","slug":"colonic-potassium-secretion","display_name":"Colonic potassium secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c2726087-c6bb-5976-932b-e9555387ed94","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-secretory-diarrhea-bk-case-event","event_type":"observed_intervention","label":"Severe potassium loss can occur through the gut even in kidney failure.","description":"Marked BK overexpression accompanied colonic potassium-secretory diarrhea and hypokalemia in the reported patient.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3774e390-948f-57ec-b2ee-052930a9ec6c","slug":"kcnma1","display_name":"Large-conductance calcium-activated potassium channel alpha subunit","entity_type_key":"protein"},"role":"overexpressed_channel","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"lost_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"095d97bd-3ce6-5f5c-b685-a678dbced325","slug":"colonic-bk-abundance","display_name":"Colonic BK channel abundance","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7ce59808-94a1-5919-a371-6640ecc42672","slug":"colonic-potassium-secretion","display_name":"Colonic potassium secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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symptoms resolved after colectomy.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-van-dinter2008] Over-expression of colonic K+ channels associated with severe potassium secretory diarrhoea after haemorrhagic shock (2008). https://pubmed.ncbi.nlm.nih.gov/18653901/ DOI: 10.1093/ndt/gfn411","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}