Component
Human mitoNEET / CISD1
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Resveratrol-3-sulfate associated with the soluble human mitoNEET domain in mass-spectrometry and calorimetry experiments, with fitted dissociation constants approximately 5–16 micromolar.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Purified soluble cytosolic domain, residues 32–108.
- limitations
- Association does not demonstrate altered iron-sulfur transfer or clinical mitochondrial benefit.
- nutrient_topic
- Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Resveratrol
- plain_language
- The sulfate metabolite has a target the parent did not share.
- primary_references
- Complexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21591687/ · DOI 10.1021/bi200546s
Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19) · lines 126–132
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Purified soluble cytosolic domain, residues 32–108. · source_derived_draft · unverified_draft
## resveratrol-mitoneet-metabolite The sulfate metabolite has a target the parent did not share. Resveratrol-3-sulfate associated with the soluble human mitoNEET domain in mass-spectrometry and calorimetry experiments, with fitted dissociation constants approximately 5–16 micromolar. Model: Purified soluble cytosolic domain, residues 32–108. Limitations: Association does not demonstrate altered iron-sulfur transfer or clinical mitochondrial benefit. Evidence access: Primary full text Complexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21591687/ · DOI 10.1021/bi200546s
Complete structured claim and evidenceParent resveratrol showed no tendency to interact with mitoNEET in the reported binding experiments.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Same purified protein study.
- limitations
- Null applies to the tested conditions.
- nutrient_topic
- Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Resveratrol
- plain_language
- Do not transfer a metabolite target to the parent.
- primary_references
- Complexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21591687/ · DOI 10.1021/bi200546s
Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19) · lines 134–140
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same purified protein study. · source_derived_draft · unverified_draft
## resveratrol-mitoneet-parent-null Do not transfer a metabolite target to the parent. Parent resveratrol showed no tendency to interact with mitoNEET in the reported binding experiments. Model: Same purified protein study. Limitations: Null applies to the tested conditions. Evidence access: Primary abstract Complexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21591687/ · DOI 10.1021/bi200546s
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.