{"id":"974a5e56-7494-5c26-951a-2538db767b8b","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-mitoneet-metabolite","predicate":"binds","statement":"Resveratrol-3-sulfate associated with the soluble human mitoNEET domain in mass-spectrometry and calorimetry experiments, with fitted dissociation constants approximately 5–16 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cbea047f-73d3-5dba-a2cc-362527696e67","mechanism_event_label":"The sulfate metabolite has a target the parent did not share.","subject":{"id":"08140d84-7366-5b7f-b3a3-e0ec20f6ae2e","slug":"resveratrol-3-o-sulfate","display_name":"Resveratrol 3-O-sulfate","entity_type_key":"small_molecule"},"object":{"id":"9f517264-473e-5d48-bc12-c5b601f38915","slug":"cisd1","display_name":"Human mitoNEET / CISD1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"cbea047f-73d3-5dba-a2cc-362527696e67","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-mitoneet-metabolite-event","event_type":"observed_relationship","label":"The sulfate metabolite has a target the parent did not share.","description":"Resveratrol-3-sulfate associated with the soluble human mitoNEET domain in mass-spectrometry and calorimetry experiments, with fitted dissociation constants approximately 5–16 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"08140d84-7366-5b7f-b3a3-e0ec20f6ae2e","slug":"resveratrol-3-o-sulfate","display_name":"Resveratrol 3-O-sulfate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9f517264-473e-5d48-bc12-c5b601f38915","slug":"cisd1","display_name":"Human mitoNEET / CISD1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"02107865-f169-5624-9ea4-9448a4cce185","slug":"iron-sulfur-2fe2s","display_name":"[2Fe-2S] iron-sulfur cluster","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified soluble cytosolic domain, residues 32–108.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association does not demonstrate altered iron-sulfur transfer or clinical mitochondrial benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The sulfate metabolite has a target the parent did not share.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Complexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21591687/ · DOI 10.1021/bi200546s","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2da8e841-e5d0-5b3d-abdf-0e42452c04e5","evidence_kind":"source_excerpt","locator":"Lines 126-132","start_line":126,"end_line":132,"excerpt":"## resveratrol-mitoneet-metabolite\nThe sulfate metabolite has a target the parent did not share.\nResveratrol-3-sulfate associated with the soluble human mitoNEET domain in mass-spectrometry and calorimetry experiments, with fitted dissociation constants approximately 5–16 micromolar.\nModel: Purified soluble cytosolic domain, residues 32–108.\nLimitations: Association does not demonstrate altered iron-sulfur transfer or clinical mitochondrial benefit.\nEvidence access: Primary full text\nComplexes of the outer mitochondrial membrane protein mitoNEET with resveratrol-3-sulfate. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21591687/ · DOI 10.1021/bi200546s","model_system":"Purified soluble cytosolic domain, residues 32–108.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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