Component
Circulating sex-hormone-binding globulin concentration
Circulating sex-hormone-binding globulin concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SHBG concentrations decreased six hours after boron supplementation in the eight-man study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/boron-research/21129941.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157", "start_char": 0, "end_char": 1706, "text_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157"}
- experimental_model
- Sequential placebo-day and supplementation observations in eight men
- exposure
- 10 mg boron/day for one week; acute six-hour and day-seven measurements
- limitations
- Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.
- nutrient_topic
- Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
- organism
- Human healthy male volunteers
- plain_language
- A hormone-carrier measurement fell in a small short study; the molecular reason was not established.
- primary_references
- [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001
- tissue_or_cell_type
- Plasma hormones and inflammatory biomarkers
Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 1002–1013
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sequential placebo-day and supplementation observations in eight men · source_derived_draft · unverified_draft
### boron-short-study-shbg SHBG concentrations decreased six hours after boron supplementation in the eight-man study. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A hormone-carrier measurement fell in a small short study; the molecular reason was not established. organism: Human healthy male volunteers tissue_or_cell_type: Plasma hormones and inflammatory biomarkers experimental_model: Sequential placebo-day and supplementation observations in eight men limitations: Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG. exposure: 10 mg boron/day for one week; acute six-hour and day-seven measurements evidence_span: {"source_cache": "artifacts/boron-research/21129941.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157", "start_char": 0, "end_char": 1706, "text_sha256": "4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157"} [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.