{"id":"a0456ea2-762b-57c5-8e48-b089ab932dbf","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-shbg","predicate":"reduces","statement":"SHBG concentrations decreased six hours after boron supplementation in the eight-man study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"cd440881-48c5-50c4-a75d-fc0c47f5f917","mechanism_event_label":"A hormone-carrier measurement fell in a small short study; the molecular reason was not established.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"d6de1c62-ee08-50c9-85cc-ac73c39b325e","slug":"circulating-shbg-concentration","display_name":"Circulating sex-hormone-binding globulin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cd440881-48c5-50c4-a75d-fc0c47f5f917","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-shbg-event","event_type":"observed_intervention","label":"A hormone-carrier measurement fell in a small short study; the molecular reason was not established.","description":"SHBG concentrations decreased six hours after boron supplementation in the eight-man study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d6de1c62-ee08-50c9-85cc-ac73c39b325e","slug":"circulating-shbg-concentration","display_name":"Circulating sex-hormone-binding globulin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sequential placebo-day and supplementation observations in eight men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10 mg boron/day for one week; acute six-hour and day-seven measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human healthy male volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A hormone-carrier measurement fell in a small short study; the molecular reason was not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma hormones and inflammatory biomarkers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ee18a2f6-7ecc-55f1-acd3-e69faa16f952","evidence_kind":"source_excerpt","locator":"Lines 1002-1013","start_line":1002,"end_line":1013,"excerpt":"### boron-short-study-shbg\nSHBG concentrations decreased six hours after boron supplementation in the eight-man study.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A hormone-carrier measurement fell in a small short study; the molecular reason was not established.\norganism: Human healthy male volunteers\ntissue_or_cell_type: Plasma hormones and inflammatory biomarkers\nexperimental_model: Sequential placebo-day and supplementation observations in eight men\nlimitations: Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.\nexposure: 10 mg boron/day for one week; acute six-hour and day-seven measurements\nevidence_span: {\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}\n[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","model_system":"Sequential placebo-day and supplementation observations in eight men","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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