Component
Circulating leukocyte ascorbate concentration
Independent measured endpoint or substance; model, assay and exposure are retained in each linked finding.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Neutrophils, monocytes and lymphocytes saturated at 100 mg/day and held vitamin C concentrations at least 14 times those in plasma.
Experimental context and source evidence
- experimental_model
- Seven healthy volunteers hospitalized for 4–6 months in a controlled depletion/repletion study.
- exposure
- Diet below 5 mg vitamin C/day, followed by seven daily doses spanning 30–2500 mg; separate single-dose bioavailability assessments.
- limitations
- Concentration is not an immune-function or infection-prevention endpoint.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Homo sapiens
- plain_language
- Blood cells can concentrate vitamin C; the surrounding plasma does not give the same number.
- primary_references
- [c-levine1996] Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance (1996). https://pubmed.ncbi.nlm.nih.gov/8623000/ DOI: 10.1073/pnas.93.8.3704
- tissue_or_cell_type
- Human circulating neutrophils, monocytes and lymphocytes
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1409–1419
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Seven healthy volunteers hospitalized for 4–6 months in a controlled depletion/repletion study. · source_derived_draft · unverified_draft
### c-leukocyte-concentration-saturation Neutrophils, monocytes and lymphocytes saturated at 100 mg/day and held vitamin C concentrations at least 14 times those in plasma. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blood cells can concentrate vitamin C; the surrounding plasma does not give the same number. organism: Homo sapiens tissue_or_cell_type: Human circulating neutrophils, monocytes and lymphocytes experimental_model: Seven healthy volunteers hospitalized for 4–6 months in a controlled depletion/repletion study. limitations: Concentration is not an immune-function or infection-prevention endpoint. exposure: Diet below 5 mg vitamin C/day, followed by seven daily doses spanning 30–2500 mg; separate single-dose bioavailability assessments. [c-levine1996] Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance (1996). https://pubmed.ncbi.nlm.nih.gov/8623000/ DOI: 10.1073/pnas.93.8.3704
Complete structured claim and evidence
Where it participates (unsigned role)
In the young-women study, plasma and circulating cells saturated at 400 mg/day, with higher doses eliminated in urine.
Experimental context and source evidence
- experimental_model
- Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study.
- exposure
- Vitamin C 30–2500 mg/day at sequential steady states. Participant count is not extracted from the inspected abstract.
- limitations
- Study differences do not establish a fixed sex-specific requirement; these are historical experimental endpoints.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Homo sapiens
- plain_language
- The measured pools reached a plateau in this separate cohort.
- primary_references
- [c-levine2001] A new recommended dietary allowance of vitamin C for healthy young women (2001). https://pubmed.ncbi.nlm.nih.gov/11504949/ DOI: 10.1073/pnas.171318198
- tissue_or_cell_type
- Human blood or whole-person endpoints
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1445–1455
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study. · source_derived_draft · unverified_draft
### c-women-plasma-saturation In the young-women study, plasma and circulating cells saturated at 400 mg/day, with higher doses eliminated in urine. Condition category: normal nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured pools reached a plateau in this separate cohort. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Healthy young women hospitalized for 186 ± 28 days in a depletion/repletion study. limitations: Study differences do not establish a fixed sex-specific requirement; these are historical experimental endpoints. exposure: Vitamin C 30–2500 mg/day at sequential steady states. Participant count is not extracted from the inspected abstract. [c-levine2001] A new recommended dietary allowance of vitamin C for healthy young women (2001). https://pubmed.ncbi.nlm.nih.gov/11504949/ DOI: 10.1073/pnas.171318198
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.