Component

Chicken ABCA1 E89K / WHAM genotype

Chicken ABCA1 E89K / WHAM genotype. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. WHAM chickens with ABCA1 E89K had over 90% lower plasma HDL.

    Chicken ABCA1 E89K / WHAM genotype → WHAM chicken circulating HDL abundance source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/lutein-research/12364545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c", "start_char": 0, "end_char": 913, "text_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c"}
    experimental_model
    WHAM sequencing and functional expression of corresponding mutation
    exposure
    Naturally occurring chicken E89K; analogous mouse protein substitution
    limitations
    Trafficking experiment used mouse protein; do not silently relabel it as human or chicken protein.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Chicken genotype and engineered mouse ABCA1
    plain_language
    A transporter mutation severely reduced a circulating carrier.
    primary_references
    [lutein-p12364545] Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. (2002). https://pubmed.ncbi.nlm.nih.gov/12364545/ DOI: 10.1194/jlr.m200223-jlr200
    tissue_or_cell_type
    Lipoprotein phenotype and cellular membrane trafficking
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 359–370

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · WHAM sequencing and functional expression of corresponding mutation · source_derived_draft · unverified_draft

    ### lutein-wham-hdl WHAM chickens with ABCA1 E89K had over 90% lower plasma HDL. Condition category: machinery_impairment nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter mutation severely reduced a circulating carrier. organism: Chicken genotype and engineered mouse ABCA1 tissue_or_cell_type: Lipoprotein phenotype and cellular membrane trafficking experimental_model: WHAM sequencing and functional expression of corresponding mutation limitations: Trafficking experiment used mouse protein; do not silently relabel it as human or chicken protein. exposure: Naturally occurring chicken E89K; analogous mouse protein substitution evidence_span: {"source_cache": "artifacts/lutein-research/12364545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c", "start_char": 0, "end_char": 913, "text_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c"} [lutein-p12364545] Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. (2002). https://pubmed.ncbi.nlm.nih.gov/12364545/ DOI: 10.1194/jlr.m200223-jlr200
    Complete structured claim and evidence

  2. WHAM chicks had retinal lutein around 6% of control levels.

    Chicken ABCA1 E89K / WHAM genotype → Chicken retinal lutein content source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/lutein-research/17724211.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4", "start_char": 0, "end_char": 1727, "text_sha256": "7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4"}
    experimental_model
    High-lutein feeding in WHAM versus control chicks
    exposure
    High-lutein or control diet from hatching for 28 days
    limitations
    Animal transport failure; raising human HDL cholesterol is not established as a way to improve retinal lutein.
    nutrient_topic
    Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
    organism
    Chicken
    plain_language
    Very little lutein reached or remained in the retina.
    primary_references
    [lutein-p17724211] The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter. (2007). https://pubmed.ncbi.nlm.nih.gov/17724211/ DOI: 10.1167/iovs.06-1275
    tissue_or_cell_type
    Plasma, retina, liver and heart
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 385–396

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · High-lutein feeding in WHAM versus control chicks · source_derived_draft · unverified_draft

    ### lutein-wham-retina WHAM chicks had retinal lutein around 6% of control levels. Condition category: machinery_impairment nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: Very little lutein reached or remained in the retina. organism: Chicken tissue_or_cell_type: Plasma, retina, liver and heart experimental_model: High-lutein feeding in WHAM versus control chicks limitations: Animal transport failure; raising human HDL cholesterol is not established as a way to improve retinal lutein. exposure: High-lutein or control diet from hatching for 28 days evidence_span: {"source_cache": "artifacts/lutein-research/17724211.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4", "start_char": 0, "end_char": 1727, "text_sha256": "7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4"} [lutein-p17724211] The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter. (2007). https://pubmed.ncbi.nlm.nih.gov/17724211/ DOI: 10.1167/iovs.06-1275
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards