{"id":"3fbe1427-c6f4-576b-b206-30035d465d51","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-wham-retina","predicate":"associated_with_low","statement":"WHAM chicks had retinal lutein around 6% of control levels.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bfa77643-9ce4-54e9-941c-053cc9b3e225","mechanism_event_label":"Very little lutein reached or remained in the retina.","subject":{"id":"3003928a-4299-5b69-85dc-764af1d8fc75","slug":"chicken-abca1-e89k","display_name":"Chicken ABCA1 E89K / WHAM genotype","entity_type_key":"protein_state"},"object":{"id":"f2bfc8e0-8200-5650-a88d-f9258fe973c4","slug":"chicken-retinal-lutein","display_name":"Chicken retinal lutein content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bfa77643-9ce4-54e9-941c-053cc9b3e225","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-wham-retina-event","event_type":"biochemical_relationship","label":"Very little lutein reached or remained in the retina.","description":"WHAM chicks had retinal lutein around 6% of control levels.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3003928a-4299-5b69-85dc-764af1d8fc75","slug":"chicken-abca1-e89k","display_name":"Chicken ABCA1 E89K / WHAM genotype","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2bfc8e0-8200-5650-a88d-f9258fe973c4","slug":"chicken-retinal-lutein","display_name":"Chicken retinal lutein content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/17724211.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"High-lutein feeding in WHAM versus control chicks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"High-lutein or control diet from hatching for 28 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal transport failure; raising human HDL cholesterol is not established as a way to improve retinal lutein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Chicken","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Very little lutein reached or remained in the retina.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p17724211] The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter. (2007). https://pubmed.ncbi.nlm.nih.gov/17724211/ DOI: 10.1167/iovs.06-1275","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma, retina, liver and heart","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"bbe1cb2d-80fb-52e4-94f3-00e84f22239b","evidence_kind":"source_excerpt","locator":"Lines 385-396","start_line":385,"end_line":396,"excerpt":"### lutein-wham-retina\nWHAM chicks had retinal lutein around 6% of control levels.\nCondition category: machinery_impairment\nnutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Very little lutein reached or remained in the retina.\norganism: Chicken\ntissue_or_cell_type: Plasma, retina, liver and heart\nexperimental_model: High-lutein feeding in WHAM versus control chicks\nlimitations: Animal transport failure; raising human HDL cholesterol is not established as a way to improve retinal lutein.\nexposure: High-lutein or control diet from hatching for 28 days\nevidence_span: {\"source_cache\": \"artifacts/lutein-research/17724211.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\"}\n[lutein-p17724211] The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter. (2007). https://pubmed.ncbi.nlm.nih.gov/17724211/ DOI: 10.1167/iovs.06-1275","model_system":"High-lutein feeding in WHAM versus control chicks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lutein-p17724211] The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter. (2007). https://pubmed.ncbi.nlm.nih.gov/17724211/ DOI: 10.1167/iovs.06-1275","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"beef4241-6ebd-5b36-864c-6ef3ed7e61b8","stable_key":"import-cfa4bd86-d88d-555a-975c-68877bf00e0f","title":"Lutein: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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