Component
WHAM chicken circulating HDL abundance
WHAM chicken circulating HDL abundance. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
WHAM chickens with ABCA1 E89K had over 90% lower plasma HDL.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/lutein-research/12364545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c", "start_char": 0, "end_char": 913, "text_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c"}
- experimental_model
- WHAM sequencing and functional expression of corresponding mutation
- exposure
- Naturally occurring chicken E89K; analogous mouse protein substitution
- limitations
- Trafficking experiment used mouse protein; do not silently relabel it as human or chicken protein.
- nutrient_topic
- Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
- organism
- Chicken genotype and engineered mouse ABCA1
- plain_language
- A transporter mutation severely reduced a circulating carrier.
- primary_references
- [lutein-p12364545] Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. (2002). https://pubmed.ncbi.nlm.nih.gov/12364545/ DOI: 10.1194/jlr.m200223-jlr200
- tissue_or_cell_type
- Lipoprotein phenotype and cellular membrane trafficking
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 359–370
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · WHAM sequencing and functional expression of corresponding mutation · source_derived_draft · unverified_draft
### lutein-wham-hdl WHAM chickens with ABCA1 E89K had over 90% lower plasma HDL. Condition category: machinery_impairment nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter mutation severely reduced a circulating carrier. organism: Chicken genotype and engineered mouse ABCA1 tissue_or_cell_type: Lipoprotein phenotype and cellular membrane trafficking experimental_model: WHAM sequencing and functional expression of corresponding mutation limitations: Trafficking experiment used mouse protein; do not silently relabel it as human or chicken protein. exposure: Naturally occurring chicken E89K; analogous mouse protein substitution evidence_span: {"source_cache": "artifacts/lutein-research/12364545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c", "start_char": 0, "end_char": 913, "text_sha256": "e3deaf99143042e2667f6be249df15574ba1f975f3b537f5b779fbe69bd20c4c"} [lutein-p12364545] Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. (2002). https://pubmed.ncbi.nlm.nih.gov/12364545/ DOI: 10.1194/jlr.m200223-jlr200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.