Component
Caco-2 efflux of chlorogenic acid
Caco-2 efflux of chlorogenic acid. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Bidirectional permeability measurements supported active efflux of chlorogenic acid.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/33336676.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713", "start_char": 0, "end_char": 1430, "text_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713"}
- experimental_model
- Bidirectional Caco-2 permeability assay
- exposure
- Chlorogenic acid and quinic acid; dosing details not provided in indexed abstract
- limitations
- Active efflux is demonstrated at the assay level. A specific ABC transporter, gene knockout result or clinical drug interaction is not established by the abstract.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Human cell line
- plain_language
- Movement back toward the gut side can limit passage across this cell model.
- primary_references
- [chlorogenic_acid-p33336676] Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay. (2021). https://pubmed.ncbi.nlm.nih.gov/33336676/ DOI: 10.1039/d0fo02629h
- tissue_or_cell_type
- Cultured intestinal epithelial barrier
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 217–228
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bidirectional Caco-2 permeability assay · source_derived_draft · unverified_draft
### chlorogenic_acid-parent-efflux Bidirectional permeability measurements supported active efflux of chlorogenic acid. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Movement back toward the gut side can limit passage across this cell model. organism: Human cell line tissue_or_cell_type: Cultured intestinal epithelial barrier experimental_model: Bidirectional Caco-2 permeability assay limitations: Active efflux is demonstrated at the assay level. A specific ABC transporter, gene knockout result or clinical drug interaction is not established by the abstract. exposure: Chlorogenic acid and quinic acid; dosing details not provided in indexed abstract evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/33336676.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713", "start_char": 0, "end_char": 1430, "text_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713"} [chlorogenic_acid-p33336676] Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay. (2021). https://pubmed.ncbi.nlm.nih.gov/33336676/ DOI: 10.1039/d0fo02629h
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.