Component

Ceylon leaf oil sample characterized in the 2023 enzyme study

Ceylon leaf oil sample characterized in the 2023 enzyme study. Species, exposure and limitations are retained in each linked claim.

6 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The leaf oil displayed cupric-ion reducing capacity in the study chemical assays.

    Ceylon leaf oil sample characterized in the 2023 enzyme study → Cinnamon oil cupric-ion reducing assay signal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"}
    experimental_model
    Composition, chemical redox and cell-free enzyme assays
    exposure
    One leaf oil sample; concentration-response assays in micrograms/mL
    limitations
    This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    C. zeylanicum leaf sample; human CA II and other assay preparations
    plain_language
    Changing copper oxidation state in an assay does not show copper absorption or depletion.
    primary_references
    [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    tissue_or_cell_type
    Leaf essential oil and purified-enzyme assays

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 181–192

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Composition, chemical redox and cell-free enzyme assays · source_derived_draft · unverified_draft

    ### ceylon-copper-reduction The leaf oil displayed cupric-ion reducing capacity in the study chemical assays. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing copper oxidation state in an assay does not show copper absorption or depletion. organism: C. zeylanicum leaf sample; human CA II and other assay preparations tissue_or_cell_type: Leaf essential oil and purified-enzyme assays experimental_model: Composition, chemical redox and cell-free enzyme assays limitations: This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment. exposure: One leaf oil sample; concentration-response assays in micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"} [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    Complete structured claim and evidence

  2. The leaf oil displayed ferric-ion reducing capacity in the study chemical assays.

    Ceylon leaf oil sample characterized in the 2023 enzyme study → Cinnamon oil ferric-ion reducing assay signal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"}
    experimental_model
    Composition, chemical redox and cell-free enzyme assays
    exposure
    One leaf oil sample; concentration-response assays in micrograms/mL
    limitations
    This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    C. zeylanicum leaf sample; human CA II and other assay preparations
    plain_language
    Changing iron oxidation state in an assay does not show better iron nutrition.
    primary_references
    [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    tissue_or_cell_type
    Leaf essential oil and purified-enzyme assays

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 168–179

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Composition, chemical redox and cell-free enzyme assays · source_derived_draft · unverified_draft

    ### ceylon-iron-reduction The leaf oil displayed ferric-ion reducing capacity in the study chemical assays. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing iron oxidation state in an assay does not show better iron nutrition. organism: C. zeylanicum leaf sample; human CA II and other assay preparations tissue_or_cell_type: Leaf essential oil and purified-enzyme assays experimental_model: Composition, chemical redox and cell-free enzyme assays limitations: This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment. exposure: One leaf oil sample; concentration-response assays in micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"} [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    Complete structured claim and evidence

  3. The leaf oil inhibited the assay acetylcholinesterase preparation, with reported IC50 16.03 micrograms/mL.

    Ceylon leaf oil sample characterized in the 2023 enzyme study → Acetylcholinesterase assay preparation in the 2023 leaf-oil study; species unresolved here source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"}
    experimental_model
    Composition, chemical redox and cell-free enzyme assays
    exposure
    One leaf oil sample; concentration-response assays in micrograms/mL
    limitations
    This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    C. zeylanicum leaf sample; human CA II and other assay preparations
    plain_language
    An enzyme assay found inhibition; this does not establish improved memory.
    primary_references
    [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    tissue_or_cell_type
    Leaf essential oil and purified-enzyme assays

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 142–153

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Composition, chemical redox and cell-free enzyme assays · source_derived_draft · unverified_draft

    ### ceylon-leaf-ache The leaf oil inhibited the assay acetylcholinesterase preparation, with reported IC50 16.03 micrograms/mL. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: An enzyme assay found inhibition; this does not establish improved memory. organism: C. zeylanicum leaf sample; human CA II and other assay preparations tissue_or_cell_type: Leaf essential oil and purified-enzyme assays experimental_model: Composition, chemical redox and cell-free enzyme assays limitations: This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment. exposure: One leaf oil sample; concentration-response assays in micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"} [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    Complete structured claim and evidence

  4. The leaf oil inhibited the assay alpha-amylase preparation, with reported IC50 7.54 micrograms/mL.

    Ceylon leaf oil sample characterized in the 2023 enzyme study → Alpha-amylase assay preparation in the 2023 leaf-oil study; species unresolved here source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"}
    experimental_model
    Composition, chemical redox and cell-free enzyme assays
    exposure
    One leaf oil sample; concentration-response assays in micrograms/mL
    limitations
    This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    C. zeylanicum leaf sample; human CA II and other assay preparations
    plain_language
    A starch-digesting enzyme was inhibited in the assay, but a meal response was not measured.
    primary_references
    [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    tissue_or_cell_type
    Leaf essential oil and purified-enzyme assays

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 155–166

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Composition, chemical redox and cell-free enzyme assays · source_derived_draft · unverified_draft

    ### ceylon-leaf-amylase The leaf oil inhibited the assay alpha-amylase preparation, with reported IC50 7.54 micrograms/mL. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: A starch-digesting enzyme was inhibited in the assay, but a meal response was not measured. organism: C. zeylanicum leaf sample; human CA II and other assay preparations tissue_or_cell_type: Leaf essential oil and purified-enzyme assays experimental_model: Composition, chemical redox and cell-free enzyme assays limitations: This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment. exposure: One leaf oil sample; concentration-response assays in micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"} [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    Complete structured claim and evidence

  5. The studied Ceylon leaf oil contained 72.98% (E)-cinnamaldehyde by its reported volatile profile.

    Ceylon leaf oil sample characterized in the 2023 enzyme study → trans-Cinnamaldehyde / cinnamal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"}
    experimental_model
    Composition, chemical redox and cell-free enzyme assays
    exposure
    One leaf oil sample; concentration-response assays in micrograms/mL
    limitations
    This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    C. zeylanicum leaf sample; human CA II and other assay preparations
    plain_language
    This particular leaf oil was cinnamaldehyde-rich; other oils can have different compositions.
    primary_references
    [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    tissue_or_cell_type
    Leaf essential oil and purified-enzyme assays

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 116–127

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Composition, chemical redox and cell-free enzyme assays · source_derived_draft · unverified_draft

    ### ceylon-leaf-ca-content The studied Ceylon leaf oil contained 72.98% (E)-cinnamaldehyde by its reported volatile profile. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: This particular leaf oil was cinnamaldehyde-rich; other oils can have different compositions. organism: C. zeylanicum leaf sample; human CA II and other assay preparations tissue_or_cell_type: Leaf essential oil and purified-enzyme assays experimental_model: Composition, chemical redox and cell-free enzyme assays limitations: This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment. exposure: One leaf oil sample; concentration-response assays in micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"} [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    Complete structured claim and evidence

  6. The leaf oil inhibited human carbonic anhydrase II in vitro, with reported IC50 243.24 micrograms/mL.

    Ceylon leaf oil sample characterized in the 2023 enzyme study → Human carbonic anhydrase II / CA2 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"}
    experimental_model
    Composition, chemical redox and cell-free enzyme assays
    exposure
    One leaf oil sample; concentration-response assays in micrograms/mL
    limitations
    This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    C. zeylanicum leaf sample; human CA II and other assay preparations
    plain_language
    The oil slowed a human enzyme in a test tube; clinical effects were not tested.
    primary_references
    [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    tissue_or_cell_type
    Leaf essential oil and purified-enzyme assays

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 129–140

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Composition, chemical redox and cell-free enzyme assays · source_derived_draft · unverified_draft

    ### ceylon-leaf-ca2 The leaf oil inhibited human carbonic anhydrase II in vitro, with reported IC50 243.24 micrograms/mL. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The oil slowed a human enzyme in a test tube; clinical effects were not tested. organism: C. zeylanicum leaf sample; human CA II and other assay preparations tissue_or_cell_type: Leaf essential oil and purified-enzyme assays experimental_model: Composition, chemical redox and cell-free enzyme assays limitations: This leaf sample is not representative of all leaf oils. Chemical reduction is not mineral absorption; enzyme inhibition is not disease treatment. exposure: One leaf oil sample; concentration-response assays in micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/36676085.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291", "start_char": 0, "end_char": 1755, "text_sha256": "c71e19c572310e80b103949f460ac437e9a564daae423e1de3f17964f2c92291"} [ceylon-p36676085] Comprehensive Metabolite Profiling of Cinnamon (Cinnamomum zeylanicum) Leaf Oil Using LC-HR/MS, GC/MS, and GC-FID: Determination of Antiglaucoma, Antioxidant, Anticholinergic, and Antidiabetic Profiles. (2023). https://pubmed.ncbi.nlm.nih.gov/36676085/ DOI: 10.3390/life13010136
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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