Component
The crystallographic model of the human CB1 receptor
The crystallographic model of the human CB1 receptor. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The crystal structure of the human CB1 receptor was determined, resolving the architecture of its ligand-binding pocket.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/27768894.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1", "start_char": 0, "end_char": 1042, "text_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1"}
- experimental_model
- X-ray crystallography of the human CB1 receptor
- exposure
- Antagonist-bound receptor crystallography
- limitations
- A structure of one conformational state with one ligand class bound. It does not by itself explain agonist efficacy differences.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Human receptor
- plain_language
- The receptor has a defined shape, and the drug fits into a specific slot in it.
- primary_references
- [thc-p27768894] Crystal Structure of the Human Cannabinoid Receptor CB1. (2016). https://pubmed.ncbi.nlm.nih.gov/27768894/ DOI: 10.1016/j.cell.2016.10.004
- tissue_or_cell_type
- Purified receptor
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 114–125
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · X-ray crystallography of the human CB1 receptor · source_derived_draft · unverified_draft
### thc-cb1-structure The crystal structure of the human CB1 receptor was determined, resolving the architecture of its ligand-binding pocket. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The receptor has a defined shape, and the drug fits into a specific slot in it. organism: Human receptor tissue_or_cell_type: Purified receptor experimental_model: X-ray crystallography of the human CB1 receptor limitations: A structure of one conformational state with one ligand class bound. It does not by itself explain agonist efficacy differences. exposure: Antagonist-bound receptor crystallography evidence_span: {"source_cache": "artifacts/thc-research/27768894.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1", "start_char": 0, "end_char": 1042, "text_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1"} [thc-p27768894] Crystal Structure of the Human Cannabinoid Receptor CB1. (2016). https://pubmed.ncbi.nlm.nih.gov/27768894/ DOI: 10.1016/j.cell.2016.10.004
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.