The CB1 ligand-binding pocket: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

A human cannabinoid receptor was cloned and found to be expressed in testis as well as brain.
Human cannabinoid receptor 1 / CB1 / CNR1 → The CB1 ligand-binding pocket source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/thc-research/1718258.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6cd532c253d8e3d3d40738876bf1ba5a38d5c678355f5e871fb5a853aa3362e0", "start_char": 0, "end_char": 1497, "text_sha256": "6cd532c253d8e3d3d40738876bf1ba5a38d5c678355f5e871fb5a853aa3362e0"}
experimental_model
Molecular cloning of the human receptor with tissue expression analysis
exposure
Expression analysis across tissues
limitations
Extends the receptor to humans and finds it outside the brain, which is the first hint that the system is not purely neural.
nutrient_topic
THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
organism
Human receptor
plain_language
The same receptor turns up in tissue far from the brain.
primary_references
[thc-p1718258] Molecular cloning of a human cannabinoid receptor which is also expressed in testis. (1991). https://pubmed.ncbi.nlm.nih.gov/1718258/ DOI: 10.1042/bj2790129
tissue_or_cell_type
Brain and testis
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 75–86
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Molecular cloning of the human receptor with tissue expression analysis · source_derived_draft · unverified_draft
### thc-cb1-human-testis A human cannabinoid receptor was cloned and found to be expressed in testis as well as brain. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The same receptor turns up in tissue far from the brain. organism: Human receptor tissue_or_cell_type: Brain and testis experimental_model: Molecular cloning of the human receptor with tissue expression analysis limitations: Extends the receptor to humans and finds it outside the brain, which is the first hint that the system is not purely neural. exposure: Expression analysis across tissues evidence_span: {"source_cache": "artifacts/thc-research/1718258.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6cd532c253d8e3d3d40738876bf1ba5a38d5c678355f5e871fb5a853aa3362e0", "start_char": 0, "end_char": 1497, "text_sha256": "6cd532c253d8e3d3d40738876bf1ba5a38d5c678355f5e871fb5a853aa3362e0"} [thc-p1718258] Molecular cloning of a human cannabinoid receptor which is also expressed in testis. (1991). https://pubmed.ncbi.nlm.nih.gov/1718258/ DOI: 10.1042/bj2790129
Complete structured claim and evidence
The crystal structure of the human CB1 receptor was determined, resolving the architecture of its ligand-binding pocket.
The crystallographic model of the human CB1 receptor → The CB1 ligand-binding pocket source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/thc-research/27768894.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1", "start_char": 0, "end_char": 1042, "text_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1"}
experimental_model
X-ray crystallography of the human CB1 receptor
exposure
Antagonist-bound receptor crystallography
limitations
A structure of one conformational state with one ligand class bound. It does not by itself explain agonist efficacy differences.
nutrient_topic
THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
organism
Human receptor
plain_language
The receptor has a defined shape, and the drug fits into a specific slot in it.
primary_references
[thc-p27768894] Crystal Structure of the Human Cannabinoid Receptor CB1. (2016). https://pubmed.ncbi.nlm.nih.gov/27768894/ DOI: 10.1016/j.cell.2016.10.004
tissue_or_cell_type
Purified receptor
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 114–125
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · X-ray crystallography of the human CB1 receptor · source_derived_draft · unverified_draft
### thc-cb1-structure The crystal structure of the human CB1 receptor was determined, resolving the architecture of its ligand-binding pocket. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The receptor has a defined shape, and the drug fits into a specific slot in it. organism: Human receptor tissue_or_cell_type: Purified receptor experimental_model: X-ray crystallography of the human CB1 receptor limitations: A structure of one conformational state with one ligand class bound. It does not by itself explain agonist efficacy differences. exposure: Antagonist-bound receptor crystallography evidence_span: {"source_cache": "artifacts/thc-research/27768894.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1", "start_char": 0, "end_char": 1042, "text_sha256": "eca46f11c563fdc4265930c57c7d856782d2130b77721d8470e779a3efaf6cc1"} [thc-p27768894] Crystal Structure of the Human Cannabinoid Receptor CB1. (2016). https://pubmed.ncbi.nlm.nih.gov/27768894/ DOI: 10.1016/j.cell.2016.10.004
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

The CB1 ligand-binding pocket