Component
Cardiac output
Independent biological entity. Read linked claims for experimental scope and context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Both beriberi cases had elevated cardiac output before treatment; output fell toward normal after thiamine treatment.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- Two-patient hemodynamic report; baseline outputs 17.3 and 7.4 L/min.
- exposure
- Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.
- limitations
- Case evidence, not a diagnostic rule; severe beriberi can have other hemodynamic patterns.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- B1 deficiency can involve excessive circulatory flow, not only a weak pumping fraction.
- primary_references
- [b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25
- tissue_or_cell_type
- Cardiovascular circulation
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1563–1573
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two-patient hemodynamic report; baseline outputs 17.3 and 7.4 L/min. · source_derived_draft · unverified_draft
### b1-beriberi-cardiac-output Both beriberi cases had elevated cardiac output before treatment; output fell toward normal after thiamine treatment. Condition category: nutrient_deficiency nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: B1 deficiency can involve excessive circulatory flow, not only a weak pumping fraction. organism: Homo sapiens tissue_or_cell_type: Cardiovascular circulation experimental_model: Two-patient hemodynamic report; baseline outputs 17.3 and 7.4 L/min. limitations: Case evidence, not a diagnostic rule; severe beriberi can have other hemodynamic patterns. exposure: Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence. [b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25
Complete structured claim and evidence
Where it participates (unsigned role)
In the second patient, systemic vascular resistance rose within one to two hours after intravenous thiamine as cardiac output fell.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- experimental_model
- Serial measurements in one of the two cases.
- exposure
- Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.
- limitations
- No specific endothelial receptor, nitric oxide pathway or direct ATP mediator was isolated.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- The abnormal circulation involved the blood vessels as well as the heart.
- primary_references
- [b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25
- tissue_or_cell_type
- Systemic vasculature
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1575–1585
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Serial measurements in one of the two cases. · source_derived_draft · unverified_draft
### b1-beriberi-vascular-resistance In the second patient, systemic vascular resistance rose within one to two hours after intravenous thiamine as cardiac output fell. Condition category: nutrient_deficiency nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The abnormal circulation involved the blood vessels as well as the heart. organism: Homo sapiens tissue_or_cell_type: Systemic vasculature experimental_model: Serial measurements in one of the two cases. limitations: No specific endothelial receptor, nitric oxide pathway or direct ATP mediator was isolated. exposure: Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence. [b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.