{"id":"a79725e9-3acd-5b7c-a20b-4f3dcb788ca6","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-beriberi-cardiac-output","predicate":"repletion_normalizes_in_cases","statement":"Both beriberi cases had elevated cardiac output before treatment; output fell toward normal after thiamine treatment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"609eea31-b7ea-5f6a-82c6-3435cfcb8852","mechanism_event_label":"B1 deficiency can involve excessive circulatory flow, not only a weak pumping fraction.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"e69dfe38-3cee-530b-a11c-facdf5f2439d","slug":"cardiac-output","display_name":"Cardiac output","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"609eea31-b7ea-5f6a-82c6-3435cfcb8852","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-beriberi-cardiac-output-event","event_type":"observed_intervention","label":"B1 deficiency can involve excessive circulatory flow, not only a weak pumping fraction.","description":"Both beriberi cases had elevated cardiac output before treatment; output fell toward normal after thiamine treatment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e69dfe38-3cee-530b-a11c-facdf5f2439d","slug":"cardiac-output","display_name":"Cardiac output","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Two-patient hemodynamic report; baseline outputs 17.3 and 7.4 L/min.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Case evidence, not a diagnostic rule; severe beriberi can have other hemodynamic patterns.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"B1 deficiency can involve excessive circulatory flow, not only a weak pumping fraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cardiovascular circulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d22dccd8-2a73-5859-a648-c29dbf67a4c2","evidence_kind":"source_excerpt","locator":"Lines 1563-1573","start_line":1563,"end_line":1573,"excerpt":"### b1-beriberi-cardiac-output\nBoth beriberi cases had elevated cardiac output before treatment; output fell toward normal after thiamine treatment.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: B1 deficiency can involve excessive circulatory flow, not only a weak pumping fraction.\norganism: Homo sapiens\ntissue_or_cell_type: Cardiovascular circulation\nexperimental_model: Two-patient hemodynamic report; baseline outputs 17.3 and 7.4 L/min.\nlimitations: Case evidence, not a diagnostic rule; severe beriberi can have other hemodynamic patterns.\nexposure: Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.\n[b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25","model_system":"Two-patient hemodynamic report; baseline outputs 17.3 and 7.4 L/min.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}